Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens.docVIP

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Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens.doc

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Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens

BMC Genomics BioMedCentral Research article Open Access Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens Chung-Ming Chang*1, Jean-Luc Coville1, Gérard Coquerelle1, David Gourichon2, Ahmad Oulmouden3 and Michèle Tixier-Boichard1 Address: 1UMR Génétique et Diversité Animales, INRA/INA P-G, Centre de Recherches de Jouy, 78352 Jouy-en-Josas, France, 2Unité Expérimentale de Génétique Factorielle Avicole, INRA, Centre de Recherches de Tours, 37380 Nouzilly, France and 3UMR Génétique Moléculaire Animale, INRA/ Université de Limoges, 87061 Limoges, France Email: Chung-Ming Chang* - chang@dga2.jouy.inra.fr; Jean-Luc Coville - ugenjlc@dga2.jouy.inra.fr; Gérard Coquerelle - ugengco@dga2.jouy.inra.fr; David Gourichon - gouricho@tours.inra.fr; Ahmad Oulmouden - oulmouden@unilim.fr; Michèle Tixier-Boichard - michele.boichard@jouy.inra.fr * Corresponding author Published: 05 February 2006 Received: 11 July 2005 Accepted: 05 February 2006 BMC Genomics 2006, 7:19 doi:10.1186/1471-2164-7-19 This article is available from: /1471-2164/7/19 ? 2006 Chang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: In chickens, three mutant alleles have been reported at the C locus, including the albino mutation, and the recessive white mutation, which is characterized by white plumage and pigmented eyes. The albino mutation was found to be a 6 bp deletion in the tyrosinase (TYR) gene. The present work describes an approach to identify the structural rearrangement in the TYR gene associated with the recessive white mutation. Results: Molecular analysis of the chicken TYR gene has revealed a major structural difference (Restriction Fragment