Correction Benchmarking tools for the alignment of functional noncodingDNA.docVIP

BMC Bioinformatics BioMedCentral Correction Open Access Correction: Benchmarking tools for the alignment of functional noncoding DNA DA Pollard*1, CM Bergman*2,3,6, J Stoye4, SE Celniker2,3 and MB Eisen2,5 Address: 1Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA, 2 Department of Genome Science, Life Science Division, Lawrence Orlando Berkeley National Laboratory, Berkeley, CA 94720, USA, 3Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, 4Technische Fakult?t, Universit?t Bielefeld, 33594 Bielefeld, Germany, 5Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA and 6Current address: Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK Email: DA Pollard* - dpollard@; CM Bergman* - cbergman@gen.cam.ac.uk; J Stoye - stoye@techfak.uni-bielefeld.de; SE Celniker - celniker@; MB Eisen - mbeisen@ * Corresponding authors Published: 08 June 2004 Received: 11 May 2004 Accepted: 08 June 2004 BMC Bioinformatics 2004, 5:73 doi:10.1186/1471-2105-5-73 This article is available from: /1471-2105/5/73 ? 2004 Pollard et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Correction The most important revisions to [1] concern BLASTZ per- formance in interspersed blocks of constrained sequences (Figures 3, 4). Figure 3 shows that the true constraint cov- erage, and therefore constraint sensitivity, of BLASTZ is much improved relative to previous results for intermedi- ate to high divergence distances ([1] Figure 5). Thus BLASTZ has increased constraint coverage relative to over- all coverage (cp. Figures 1C 1D with 3A 3B), indicat- ing that BLASTZ local alignments preferentially occur in constrained sequences for intermediate