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Cyclin D1 and Rb protein expression and their correlation with prognosis in patients with colon cancer.doc

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Cyclin D1 and Rb protein expression and their correlation with prognosis in patients with colon cancer

World Journal of Surgical Oncology BioMedCentral Research Open Access Cyclin D and Rb protein expression and their correlation with 1 prognosis in patients with colon cancer Gregory Kouraklis*1, Stamos Theocharis2, Panayiotis Vamvakas1, Costas Vagianos3, Andromahi Glinavou1, Costas Giaginis1,2 and Crysoula Sioka1 Address: 1Second Department of Propedeutic Surgery, Medical School University of Athens, Laiko General Hospital, Athens, Greece, 2Laboratory of Forensic Medicine and Toxicology, Medical School University of Athens, Laiko General Hospital, Athens, Greece and 3Department of Surgery, University of Patras, Greece Email: Gregory Kouraklis* - gkouraklis@; Stamos Theocharis - statheocharis@; Panayiotis Vamvakas - gkouraklis@; Costas Vagianos - vagian@otenet.gr; Andromahi Glinavou - anicglin@; Costas Giaginis - kgiagin@; Crysoula Sioka - csioka@ * Corresponding author Published: 20 January 2006 Received: 23 August 2005 Accepted: 20 January 2006 World Journal of Surgical Oncology 2006, 4:5 doi:10.1186/1477-7819-4-5 This article is available from: /content/4/1/5 ? 2006 Kouraklis et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Cyclin D1 plays a major role as a potential contributor to the multistep process of oncogenesis; nevertheless its prognostic significance in colon cancer has already been examined in a few studies and needs to be further delineated. The aim of this study was to assess the expression of cyclin D1 and pRb and to correlate them with tumor histological stage and grade, proliferative capacity (Ki-67 labeling index) and clinical parameters, in order to delineate their impact on prognosis. Methods: One hundred and eleven patients, who underwent surgical resec