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Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection.doc

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Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection

Virology Journal BioMedCentral Short report Open Access Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection Matthijs Raaben1, Alexandra WC Einerhand2, Lucas JA Taminiau2, Michel van Houdt2, Janneke Bouma2, Rolien H Raatgeep2, Hans A Büller2, Cornelis AM de Haan1 and John WA Rossen*2,3,4 Address: 1Virology Division, Department of Infectious Diseases Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, 2Laboratory of Pediatrics, Erasmus MC- Sophia Childrens Hospital, Rotterdam, The Netherlands, 3Department of Virology, Eijkman- Winkler Institute, University Medical Centre Utrecht, Utrecht, The Netherlands and 4Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital, Tilburg, The Netherlands Email: Matthijs Raaben - m.raaben@vet.uu.nl; Alexandra WC Einerhand - a.einerhand@erasmusmc.nl; Lucas JA Taminiau - taminiau42@; Michel van Houdt - Michel.Vanhoudt@hu.nl; Janneke Bouma - j.bouma@erasmusmc.nl; Rolien H Raatgeep - h.raatgreep@erasmusmc.nl; Hans A Büller - h.buller@erasmusmc.nl; Cornelis AM de Haan - c.a.m.dehaan@vet.uu.nl; John WA Rossen* - j.rossen@elisabeth.nl * Corresponding author Published: 7 June 2007 Received: 28 April 2007 Accepted: 7 June 2007 Virology Journal 2007, 4:55 doi:10.1186/1743-422X-4-55 This article is available from: /content/4/1/55 ? 2007 Raaben et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different