Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes Interplay and Therapeutic Opportunities英文文献资料.docVIP

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Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes Interplay and Therapeutic Opportunities英文文献资料.doc

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Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes Interplay and Therapeutic Opportunities英文文献资料

HindawiPublishingCorporation InternationalJournalofHypertension Volume2012,ArticleID829786,5pages doi:10.1155/2012/829786 ReviewArticle AngiotensinII,Aldosterone,andAnti-In?ammatory Lymphocytes:InterplayandTherapeuticOpportunities DanielArthurB.Kasal andErnestoL.Schiffrin 1 2 1 DepartamentodeCl′?nicaM′edica,FaculdadedeCi?enciasM′edicas,UniversidadedoEstadodoRiodeJaneiro,Avenida.28deSetembro 77,3 .andar,Sala329,VilaIsabel,20551-030RiodeJaneiro,RJ,Brazil o 2 DepartmentofMedicineandLadyDavisInstituteforMedicalResearch,SirMortimerB.Davis-JewishGeneralHospital, McGillUniversity,Montreal,QC,CanadaH3T1E2 CorrespondenceshouldbeaddressedtoDanielArthurB.Kasal,kasald@ Received16January2012;Accepted13March2012 AcademicEditor:MarioFritschNeves Copyright?2012D.A.B.KasalandE.L.Schi?rin. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. In?ammationisrecognizedasanimportantfactorinthepathophysiologyofhypertension,withtherenin-angiotensin-aldosterone system(RAAS)playingakeyroleinthedisease.Initiallydescribedbecauseofitscontributiontoextracellular?uidandelectrolyte homeostasis,theRAAShasbeenimplicatedinendothelialdysfunction,vascularremodeling,oxidativestress,proin?ammatory cytokineproduction,andadhesionmoleculesynthesisbythevascularwall.BothangiotensinIIandaldosteroneareinvolvedin thesesystemice?ects,activatinginnateandadaptiveimmuneresponses.ThispaperhighlightssomeaspectsconnectingRAASto thehypertensivephenotype,basedonexperimentalandclinicalstudies,withemphasisonnew?ndingsregardingthecontribution ofanincreasinglystudiedpopulationofTlymphocytes:theT-regulatorylymphocytes.Thesecellscansuppressin?ammationand mayexertbene?cialvasculare?ectsinanimalmodelsofhypertension. 1.Introduction suggestedthatresearchonarterialhypertensionwouldsoon lead to the replacement of the rather unspeci?c essential hypertensionbyan