Antidepressant and cognitive activities of intranasal piperine-encapsulated liposomes英文文献资料.docVIP

Advances in Bioscience and Biotechnology, 2011, 2, 108-116 ABB doi:10.4236/abb.2011.22017 Published Online April 2011 (http://www.SciRP.org/journal/abb/). Antidepressant and cognitive activities of intranasal piperine-encapsulated liposomes Aroonsri Priprem *, Pennapa Chonpathompikunlert , Saengrawee Sutthiparinyanont , 1 2 3 4 Jintanaporn Wattanathorn 1 2 3 4 Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand; Department of Physiology (Neuroscience Graduate Program), Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand; Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Email: aroonsri@kku.ac.th; bus_pennapa@; saengrawees@; jintanapornw@ Received 20 January 2011; revised 8 March 2011; accepted 20 March 2011. ABSTRACT dase (MAO) activity [1,3,9] and increases the level of noradrenaline and serotonin in mouse brain [3], indi- cating its potential neurological benefits. Piperine could affect hippocampal neurogenesis in chronic mild stressed mice in which the level of brain-derived neu- rotrophic factor decreased. At a dose between 5 - 20 mg/kg body weight given to cholinergic-deficient rats, induced by AF64A, piperine could attenuate the in- crease in lipid peroxidation and acetylcholinesterase activity [10]. Results from cell survival and the level of brain-derived neurotrophic factor in corticosterone-treated cultured hippocampal neurons confirm similar findings [11], yet the mechanism of actions of piperine on neu- ronal damage is still unknown. The toxicity of piperine has been reported at an oral dose of 10 and 20 mg/kg body weight for 30 days [12,1