Antidepressant Drugs for Chronic Urological Pelvic Pain An Evidence-Based Review英文文献资料.docVIP

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Antidepressant Drugs for Chronic Urological Pelvic Pain An Evidence-Based Review英文文献资料.doc

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Antidepressant Drugs for Chronic Urological Pelvic Pain An Evidence-Based Review英文文献资料

HindawiPublishingCorporation AdvancesinUrology Volume2009,ArticleID797031,9pages doi:10.1155/2009/797031 ReviewArticle AntidepressantDrugsforChronicUrologicalPelvicPain: AnEvidence-BasedReview ChristosPapandreou, 1PetrosSkapinakis,1,2DimitriosGiannakis,3 NikolaosSo?kitis, andVenetsanosMavreas 2 3 1 2 3 PostgraduateProgramintheManagementofPain,UniversityofIoanninaSchoolofMedicine,Greece DepartmentofPsychiatry,UniversityofIoanninaSchoolofMedicine,Greece DepartmentofUrology,UniversityofIoanninaSchoolofMedicine,Greece CorrespondenceshouldbeaddressedtoChristosPapandreou,cpapas@otenet.gr Received29July2009;Accepted28December2009 RecommendedbyFlavioTrigoRocha Theuseofantidepressantdrugsforthemanagementofchronicpelvicpainhasbeensupportedinthepast.Thisstudyaimedto evaluatetheavailableevidenceforthee?cacyandacceptabilityofantidepressantdrugsinthemanagementofurologicalchronic pelvicpain.Studieswereselectedthroughacomprehensiveliteraturesearch.Weincludedalltypesofstudydesignsduetothe limitedevidence.Studieswereclassi?edintolevelsofevidenceaccordingtotheirdesign.Tenstudieswereincludedwithatotalof 360patients.Amitriptyline,sertraline,duloxetine,nortriptyline,andcitalopramaretheantidepressantsthathavebeenreported intheliterature.Onlyfourrandomizedcontrolledtrials(RCTs)wereidenti?ed(twoforamitriptylineandtwoforsertraline)with mixedresults.Weconcludethattheuseofantidepressantsforthemanagementofchronicurologicalpelvicpainisnotadequately supportedbymethodologicallysoundRCTs.Fromtheexistingstudiesamitriptylinemaybee?ectiveininterstitialcystitisbut publicationbiasshouldbeconsideredasanalternativeexplanation.Alldrugsweregenerallywelltoleratedwithnoseriousevents reported. Copyright?2009ChristosPapandreouetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. 1.Introduction evidence of infection or other obvious pathology [4]. Therefore,concerningtheuro