Antihepatotoxic Effect of Feronia Limonia Fruit against Carbon Tetrachloride Induced Hepatic Damage in Albino Rats英文文献资料.docVIP

Chinese Medicine, 2010, 1, 18-22 doi:10.4236/cm.2010.11003 Published Online June 2010 (http://www.SciRP.org/journal/cm) Antihepatotoxic Effect of Feronia Limonia Fruit against Carbon Tetrachloride Induced Hepatic Damage in Albino Rats Rucha Upadhyay , Narendra Deo Pandey , Shahid Suhail Narvi , Amita Verma , Bahar Ahmed 1 1 1 2 2 1 Department of Chemistry Motilal Nehru National Institute of Technology, Allahabad, India 2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delh, India E-mail: rucha.upadhyay@ Received March 10, 2010; revised April 28, 2010; accepted May 10, 2010 Abstract Feronia limonia Swingle, though mentioned as a high utility medicinal plant in Ayurveda for the treatment of liver disorders, but has no scientific investigations. Therefore, the present study was undertaken to inves- tigate the hepatoprotective activity of extracts of Feronia limonia fruit on albino rat liver, damage induced by single dose of carbon-tetrachloride (1.5 ml/kg, p.o.). The oral administration of extracts (500 mg/kg, p.o.) for 7 days has shown significant hepatoprotective action. There is reduction in the elevated levels of serum en- zymes such SGOT, SGPT, ALP and Serum bilirubin and elevation in level of GSH, GPX,GLY and total pro- tein in Feronia limonia protected rats. Keywords: Anti-Hepatotoxic, Carbon Tetrachloride, Feronia Limonia Swingle 1. Introduction 2. Experimental Feronia limonia Swingle (Syn. Feronia elephantum Correa, Fam Rutaceae) are described in ayurvedic litera- ture as Kapittha is a moderate-sized tree with straight sharp strong spines, 1.2-3.7 cm long, which is widely distributed throughout Bangladesh, Srilanka, Java and India [1-3]. The fruits of the plant are edible and consid- ered