Application of the Filariasis CELISA Antifilarial Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific英文文献资料.docVIP

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Application of the Filariasis CELISA Antifilarial Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific英文文献资料.doc

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Application of the Filariasis CELISA Antifilarial Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific英文文献资料

HindawiPublishingCorporation JournalofTropicalMedicine Volume2011,ArticleID492023,8pages doi:10.1155/2011/492023 ResearchArticle ApplicationoftheFilariasisCELISAAnti?larial IgG4AntibodyAssayinSurveillanceinLymphaticFilariasis EliminationProgrammesintheSouthPaci?c HayleyJoseph, 1 FuataiMaiava, Malakai‘Ake, 2TakeNaseri,3,4FasihahTaleo,5 6 andWayneMelrose 1 CorinneCapuano, 7 1 LymphaticFilariasisSupportCentre,SchoolofPublicHealth,TropicalMedicineandRehabilitationSciences, JamesCookUniversity,Townsville,QLD4811,Australia WorldHealthOrganization,Apia,Samoa MinistryofHealth,Apia,Samoa NationalHealthService,Apia,Samoa VectorBorneDiseaseUnit,MinistryofHealth,PortVila,Vanuatu MinistryofHealth,P.O.Box59,Nuku’alofa,Tonga WorldHealthOrganization,50490KualaLumpur,Malaysia 2 3 4 5 6 7 CorrespondenceshouldbeaddressedtoHayleyJoseph,hayley.joseph@.au Received26May2011;Accepted21July2011 AcademicEditor:AdityaPrasadDash Copyright?2011HayleyJosephetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Eliminationoflymphatic?lariasis(LF)inthePaci?cIslandCountriesandTerritories(PICT)hasbeende?nedas0.1%circulating ?larialantigen(CFA)prevalenceinchildrenbornaftertheimplementationofsuccessfulmassdrugadministrations(MDAs).This researchassessedthefeasibilityofCFAandantibodytestinginthreecountries;Tonga, Vanuatu,andSamoa. Transmissionis interruptedinVanuatuandTongaasevidencedbynoCFApositivechildrenandalowantibodyprevalenceandtitre.Transmission isongoinginSamoawithmicro?laraemic(Mf)andCFApositivechildrenandahighantibodyprevalenceandtitre.Furthermore, areasoftransmissionwereidenti?edwithMfpositiveadults,butnoCFApositivechildren.Theseareashadahighantibody prevalenceinchildren.Inconclusion,CFAtestinginchildrenalonewasnotusefulforidentifyingareasofresidualendemicityin Samoa.Thus,itwouldbebene?cialtoincludeantibodyserol