Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans Responses to Ephedrine英文文献资料.docVIP

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Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans Responses to Ephedrine英文文献资料.doc

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Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans Responses to Ephedrine英文文献资料

HindawiPublishingCorporation JournalofObesity Volume2011,ArticleID210484,8pages doi:10.1155/2011/210484 ResearchArticle AssessmentofAcuteandChronicPharmacologicalEffectson EnergyExpenditureandMacronutrientOxidationinHumans: ResponsestoEphedrine AntonellaNapolitano, 1 PeterR.Murgatroyd, 2 NickFiner, 2 ElizabethK.Hussey, 3 RobertDobbins, SteveO’Rahilly, 3 2 andDerekJ.R.Nunez 3 1 ClinicalUnitinCambridge,GlaxoSmithKline,ACCI,CambridgeUniversityHospitalsNHSFoundationTrust,HillsRoad, CambridgeCB22QQ,UK 2 3 WellcomeTrustClinicalResearchFacility,CambridgeUniversityHospitalsNHSFoundationTrust,CambridgeCB22QQ,UK MetabolicPathwaysCenterofExcellenceforDrugDiscovery,GlaxoSmithKlineResearchTrianglePark,NC27709,USA CorrespondenceshouldbeaddressedtoAntonellaNapolitano,antonella.2.napolitano@ Received17May2010;Accepted6July2010 AcademicEditor:L.VanGaal Copyright?2011AntonellaNapolitanoetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Evidenceofactivebrownadiposetissueinhumanadultssuggeststhatthismaybecomeapharmacologicaltargettoinducenegative energybalance.Wehaveexploredwhole-bodyindirectcalorimetrytodetectthemetabolice?ectsofthermogenicdrugsthrough administrationofephedrinehydrochlorideandhaveassessedephedrine’smeritsasacomparatorcompoundintheevaluation ofnovelthermogenicagents.Volunteersrandomlygivenephedrinehydrochloride15mgQID(n = 8)orplacebo(n = 6)were studiedatbaselineandafter1-2and14-15daysoftreatment.Wedemonstratethatovernightor23-hour,2%energyexpenditure (EE)and5%fat(FO)orCHOoxidatione?ectsaredetectablebothacutelyandover14days.Comparedtoplacebo,ephedrine increasedEEandFOratesovernight(EE63kJday2,EE105kJ,FO190kJ,day14),butnotover23h.Weconcludethatmodest energyexpenditureandfatoxidationresponsestopharmacologicalinterventionscanbecon?dentlydetectedbycalorimetryin smallgroups.Ephedrineshouldprovidereliabledataaga