Application of an Integrative Computational Framework in Trancriptomic Data of Atherosclerotic Mice Suggests Numerous Molecular Players英文文献资料.docVIP

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Application of an Integrative Computational Framework in Trancriptomic Data of Atherosclerotic Mice Suggests Numerous Molecular Players英文文献资料.doc

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Application of an Integrative Computational Framework in Trancriptomic Data of Atherosclerotic Mice Suggests Numerous Molecular Players英文文献资料

HindawiPublishingCorporation AdvancesinBioinformatics Volume2012,ArticleID453513,9pages doi:10.1155/2012/453513 ResearchArticle ApplicationofanIntegrativeComputationalFrameworkin TrancriptomicDataofAtheroscleroticMiceSuggestsNumerous MolecularPlayers OlgaPapadodima, AllanSirsj¨o, FragiskosN.Kolisis, andAristotelisChatziioannou 1 2 3 1 1 MetabolicEngineeringandBioinformaticsProgram,InstituteofBiologicalResearchandBiotechnology,NationalHellenicResearch Foundation,48Vas.ConstantinouAvenue,11635Athens,Greece 2 3 DivisionofClinicalMedicine,SchoolofHealthandMedicalSciences,O¨rebroUniversity,O¨rebroSE-70182,Sweden BiotechnologyLaboratory,SchoolofChemicalEngineering,ZografouCampus,NationalTechnicalUniversityofAthens, 15780Athens,Greece CorrespondenceshouldbeaddressedtoAllanSirsj¨o,allan.sirsjo@oru.seandAristotelisChatziioannou,achatzi@eie.gr Received25May2012;Accepted21September2012 AcademicEditor:KonstantinaNikita Copyright?2012OlgaPapadodimaetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Atherosclerosisisamultifactorialdiseaseinvolvingalotofgenesandproteinsrecruitedthroughoutitsmanifestation.Thepresent studyaimstoexploitbioinformatictoolsinordertoanalyzemicroarraydataofatheroscleroticaorticlesionsofApoEknockout mice,amodelwidelyusedinatherosclerosisresearch.Inparticular,adynamicanalysiswasperformedamongyoungandaged animals,resultinginalistof852signi?cantlyalteredgenes.Pathwayanalysisindicatedalterationsincriticalcellularprocesses related to cell communication and signal transduction, immune response, lipid transport, and metabolism. Cluster analysis partitionedthesigni?cantlydi?erentiatedgenesinthreemajorclustersofsimilarexpressionpro?le.Promoteranalysisapplied to functional related groups of the same cluster revealed shared putative cis-elements po