Benefits of Zataria multiflora Boiss in Experimental Model of Mouse Inflammatory Bowel Disease英文文献资料.docVIP

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Benefits of Zataria multiflora Boiss in Experimental Model of Mouse Inflammatory Bowel Disease英文文献资料.doc

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Benefits of Zataria multiflora Boiss in Experimental Model of Mouse Inflammatory Bowel Disease英文文献资料

AdvanceAccessPublication14September2006 eCAM2007;4(1)43–50 doi:10.1093/ecam/nel051 OriginalArticle BenefitsofZatariamultifloraBoissinExperimentalModelofMouse InflammatoryBowelDisease LeilaAshtaralNakhai1,AzadehMohammadirad1,NargesYasa2,BagherMinaie3, ShekoufehNikfar1,GhazalGhazanfari1,MohammadJafarZamani1,GholamrezaDehghan1, HamidrezaJamshidi1,VahidShetabBoushehri1,RezaKhorasani1and MohammadAbdollahi1 1LaboratoryofToxicology,DepartmentofToxicologyandPharmacology,FacultyofPharmacy,andPharmaceutical SciencesResearchCenter, 2LaboratoryofPharmacognosy,FacultyofPharmacyandMedicinalPlants ResearchCenterand 3LaboratoryofHistopathology,SchoolofMedicine,TehranUniversityof MedicalSciences,Tehran,Iran Inflammatory bowel disease (IBD) is a chronic condition of the intestine with unknown etiology involvingmultipleimmune,geneticandenvironmentalfactors.Wewereinterestedtoexaminetheeffect oftotalextractfrom ZatariamultifloraBoiss,afolkmedicinalplantonprevention andtreatmentof experimentalIBD.Z.multiflorawasadministered(400,600,900p.p.m.)throughdrinkingwatertoIBD miceinducedbyintrarectaladministrationofaceticacid.Prednisolonewasusedasthestandarddrugfor comparison. Biochemical, macroscopic and microscopic examinations of colon were performed. Biochemicalevaluationofinflamedcolonwasdoneusingassayofmyeloperoxidase(MPO)activityand thiobarbituricacidreactivesubstances(TBARS)concentrationasindicatorsoffreeradicalactivityand cell lipid peroxidation. The activity of MPO and lipid peroxidation products (TBARS) increased in acetic acid-treated groups while recovered by pretreatment of animals with Z. multiflora (400–900 p.p.m.)andprednisolone.Z.multiflora(600and900p.p.m.)andprednisolone-treatedgroupsshowed significantlylowerscorevaluesofmacroscopicandmicroscopiccharacterswhencomparedwiththe aceticacid-treatedgroup.ThebeneficialeffectofZ.multiflora(900p.p.m.)wascomparablewiththatof prednisolone.Theantioxidant,antimicrobialandanti-inflammatorypotentialsofZ.multifloramightbe the mechan