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Bioactive Food Components and Cancer-Specific Metabonomic Profiles英文文献资料.doc

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Bioactive Food Components and Cancer-Specific Metabonomic Profiles英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2011,ArticleID721213,9pages doi:10.1155/2011/721213 ReviewArticle BioactiveFoodComponentsandCancer-Speci?c MetabonomicPro?les YoungS.KimandJohnA.Milner NutritionalScienceResearchGroup,DivisionofCancerPrevention,NationalCancerInstitute,NationalInstitutesofHealth, Bethesda,MD20892,USA CorrespondenceshouldbeaddressedtoYoungS.Kim,yk47s@ Received16June2010;Revised29September2010;Accepted5October2010 AcademicEditor:OlavKvalheim Copyright?2011Y.S.KimandJ.A.Milner.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Cancercellspossessuniquemetabolicsignaturescomparedtonormalcells,includingshiftsinaerobicglycolysis,glutaminolysis, and de novo biosynthesis of macromolecules. Targeting these changes with agents (drugs and dietary components) has been employedasstrategiestoreducethecomplicationsassociatedwithtumorigenesis.Thispaperhighlightstheabilityofseveralfood componentstosuppresstumor-speci?cmetabolicpathways,includingincreasedexpressionofglucosetransporters,oncogenic tyrosinekinase,tumor-speci?cM2-typepyruvatekinase,andfattyacidsynthase,andthedetectionofsuche?ectsusingvarious metabonomictechnologies,includingliquidchromatography/massspectrometry(LC/MS)andstableisotope-labeledMS.Stable isotope-mediatedtracingtechnologieso?erexcitingopportunitiesforde?ningspeci?ctarget(s)forfoodcomponents.Exposures, especially during the early transition phase from normal to cancer, are critical for the translation of knowledge about food components into e?ective prevention strategies. Although appropriate dietary exposures needed to alter cellular metabolism remaininconsistentand/orill-de?ned,validatedmetabonomicbiomarkersfordietarycomponentsholdpromiseforestablishing e?ectivestrategiesforcancerprevention. 1.Introduction candidate technologies such as stable isotope monitoring [11]. Can