Bioactive Markers Based Pharmacokinetic Evaluation of Extracts of a Traditional Medicinal Plant, Piper sarmentosum英文文献资料.docVIP

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Bioactive Markers Based Pharmacokinetic Evaluation of Extracts of a Traditional Medicinal Plant, Piper sarmentosum英文文献资料.doc

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Bioactive Markers Based Pharmacokinetic Evaluation of Extracts of a Traditional Medicinal Plant, Piper sarmentosum英文文献资料

HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2011,ArticleID980760,7pages doi:10.1093/ecam/nep143 OriginalArticle BioactiveMarkersBasedPharmacokineticEvaluationof ExtractsofaTraditionalMedicinalPlant,Pipersarmentosum KhalidHussain,ZhariIsmail,AmirinSadikun,andPazillahIbrahim DepartmentofPharmaceuticalChemistry,SchoolofPharmaceuticalSciences,UniversitiSainsMalaysia, PulauPinang11800,Malaysia CorrespondenceshouldbeaddressedtoKhalidHussain,hussain761@ Received4February2009;Accepted25August2009 Copyright?2011KhalidHussainetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Invitroassaysareeconomicalandeasytoperformbuttoestablishrelevanceoftheirresultstorealclinicaloutcomeinanimals orhuman,pharmacokineticsisprerequisite.DespitevariousinvitropharmacologicalactivitiesofextractsofPipersarmentosum, thereisnoreportofpharmacokinetics.Therefore,thepresentstudyaimedtoevaluateethanolextractoffruitoftheplantindoseof 500mgkg?1orallyforpharmacokinetics.Sprague-Dawleyratswererandomlydividedintogroups1,2,and3(eachn=6)tostudy absorption,distributionandexcretion,respectively.Highperformanceliquidchromatography(HPLC)withultravioletdetection wasappliedtoquantifypellitorine,sarmentineandsarmentosineinplasma,tissues,fecesandurinetocalculatepharmacokinetic parameters.Pellitorineexhibitedmaximumplasmaconcentration(Cmax)34.77ngmL?1± 1.040,timetoachieveCmax(Tmax)8h, meanresidenttime(MRT)26.00± 0.149handhalflife(t1/2)18.64± 1.65h.SarmentineshowedC 191.50± 12.69ngmL?1 , max 6h,MRT11.12 ± 0.44handt 10.30 ± 1.98h.Sarmentosineexhibited zerooralbioavailabilitybecauseitwasneither T max 1/2 detectedinplasmanorintissues,andinurine.Pellitorinewasfoundtobedistributedinintestinalwall,liver,lungs,kidney,and heart,whereassarmentinewasfoundonlyinintestinalwallandheart.Thecumulativeexcretionofpellitorine,sarmentineand sarme