Biological effects of EV71 infection in neural cells英文文献资料.docVIP

Vol.1, No.2, 113-118 (2010) Journal of Biophysical Chemistry doi:10.4236/jbpc.2010.12014 Biological effects of EV71 infection in neural cells* Xia Cao , Li-Chun Wang , Long-Ding Liu , Yun Liao , Cheng-Hong Dong , Qi-Han Li 1# 2# 2 2 2 2** Department of Immunology and Microbiology, Kunming Medical College, Kunming, China; #Both authors contributed equally to this work Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China; 1 2 **Corresponding Author: imbcams.lq@ Received 23 May 2010; revised 25 June 2010; accepted 30 June 2010. ABSTRACT great importance. A number of studies have reported the development of a mouse-adapted HEV71 strain and new- born mice infected with mouse-adapted HEV71 [8-10]. These evidence suggests that rodents are not resistant to EV71 infection. Etiological studies of EV71 have so far not provided a good explanation of how EV71 infects neural cells, mainly because there is no established neu- ral cell tissue culture model. In our work, we used a primary rat nerve cell line to examine the basic biologi- cal characteristics of the process of EV71 infection in neural cells, as well as the pathological changes caused by EV71 infection in rats. Thus, a basic biological study of EV71 infection in neural cells is provided in this article. Enterovirus 71 (EV71) can cause serious nerv- ous system lesions but to date the pathogene- sis has been unclear. Our results show that EV71 proliferates in the neural cells and leads to neural cell lesions. The study of the pathology of EV71 infection in neonatal rat brains shows that the invasive ability of EV71 to the nervous system in vivo may depend on many unknown factors. Keywords