Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein JClusterin in Welders英文文献资料.docVIP

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Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein JClusterin in Welders英文文献资料.doc

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Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein JClusterin in Welders英文文献资料

HindawiPublishingCorporation BioinorganicChemistryandApplications Volume2008,ArticleID420578,6pages doi:10.1155/2008/420578 ResearchArticle BiologicalMonitoringofHexavalentChromiumand SerumLevelsoftheSenescenceBiomarkerApolipoprotein J/ClusterininWelders EvangelosC.Alexopoulos,1XenophonCominos,2IoannisP.Trougakos,3MagdaLourda,3 EfstathiosS.Gonos,3andVassiliosMakropoulos2 1 2 3 DepartmentofPublicHealth,MedicalSchool,UniversityofPatras,26500RioPatras,Greece HellenicInstituteforOccupationalHealthandSafety,6ThirsiouStreet,10445Athens,Greece NationalHellenicResearchFoundation,InstituteofBiologicalResearchandBiotechnology, 48Vas.ConstantinouAvenue,11635Athens,Greece CorrespondenceshouldbeaddressedtoEvangelosC.Alexopoulos,ecalexop@upatras.gr Received26August2007;Revised12January2008;Accepted13March2008 RecommendedbyGuillermoMendoza-Diaz Weldingfumescontainmetalsandothertoxicsubstancesknownorstronglysuspectedtoberelatedwithoxidativestressand prematurecellularsenescence.ApolipoproteinJ/Clusterin(ApoJ/CLU)isaglycoproteinthatisdi?erentiallyregulatedinvarious physiologicalanddiseasestatesincludingageingandage-relateddiseases.Invitrodatashowedthatexposureofhumandiploid ?broblaststohexavalentchromium(Cr(VI))resultedinprematuresenescenceandsigni?cantupregulationoftheApoJ/CLUpro- tein.Inthisstudyweanalyzedbloodandurinesamplesfromshipyardindustryweldersbeingexposedtodi?erentlevelsofCr(VI) overaperiodof?vemonthsinordertoassayinvivotherelationofApoJ/CLUserumlevelswithCr(VI).Our?ndingscon?rmed thepreviouslyreportedinvitrodatasincereductionofCrlevels,afteraworksiteintervention,associatedwithlowerlevelsof ApoJ/CLUserumlevels.WeconcludedthatthehumanApoJ/CLUgeneisresponsivetotheacuteinvivooxidativestressinduced byheavymetalssuchashexavalentchromium. Copyright?2008EvangelosC.Alexopoulosetal. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited.