Biological Significance of HCV in Various Kinds of Lymphoid Cells英文文献资料.docVIP

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Biological Significance of HCV in Various Kinds of Lymphoid Cells英文文献资料.doc

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Biological Significance of HCV in Various Kinds of Lymphoid Cells英文文献资料

HindawiPublishingCorporation InternationalJournalofMicrobiology Volume2012,ArticleID647581,7pages doi:10.1155/2012/647581 ReviewArticle BiologicalSigni?canceofHCVinVariousKindsof LymphoidCells YasuteruKondo,YoshiyukiUeno,andTooruShimosegawa DivisionofGastroenterology,TohokuUniversityHospital,1-1Seiryo-Machi,Aoba-ku,SendaiCity,Miyagi980-8574,Japan CorrespondenceshouldbeaddressedtoYasuteruKondo,yasuteru@ebony.plala.or.jp Received16September2011;Accepted12December2011 AcademicEditor:DavidC.Straus Copyright?2012YasuteruKondoetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. IthasbeenreportedthatHCVcaninfectnotonlyhepatocytesbutalsovariouskindsoflymphoidcells.Althoughmanyreports havedescribedthebiologicalsigni?canceoflymphotropicHCV,theissueremainscontroversialsincethetargetlymphoidcells mighthavevariouskindsoffunctionsintheimmunesystem.OneoftheimportantrolesoflymphoidcellsinHCVreplicationis beingareservoirofHCV.SeveralgroupsdescribedthedetectionofHCV-RNAinlymphoidcellsafterHCVeradicationinplasma. AnotherimportantroleoflymphotropicHCVisthatitactsasacarcinogenicagentandinducesimmunedysfunction.Inthis paper,wesummarizethereportsregardingthebiologicalsigni?canceoflymphotropicHCVinrepresentativelymphoidcells. 1.Introduction (SB), which was established from an HCV-positive B-cell lymphoma,caninfectandreplicateinestablishedB-celllines (Raji, Daudi) and primary B lymphocytes [23]. Moreover, we reported that two T-cell lines (Molt-4 and Jurkat) and primaryna¨?veTlymphocyteswereinfectedwithSBculture supernatant[13,27,28].Machidaetal.reportedthatHCV replicationinBlymphocytescouldcontributetothecarcino- genesisofBcellsbasedonthisusefulinvitrosystem[29,30]. Not only Machida’s group but also many groups reported theevidenceofHCVreplicationinlymphoidcells[18,31– 38].Variousstudiesaboutthebiologicalsigni?canceofHCV infection in ly