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Biologics in Paediatric Crohns Disease英文文献资料.doc

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Biologics in Paediatric Crohns Disease英文文献资料

HindawiPublishingCorporation GastroenterologyResearchandPractice Volume2011,ArticleID287574,10pages doi:10.1155/2011/287574 ReviewArticle BiologicsinPaediatricCrohn’sDisease OliverGouldthorpe,1,2AnthonyG.Catto-Smith,2,3,4andGeorgeAlex 2,3 1 2 3 4 DepartmentofPaediatrics,MonashUniversity,Clayton,VIC3800,Australia DepartmentofGastroenterologyandClinicalNutrition,RoyalChildren’sHospital,ParkvilleMelbourne,VIC3052,Australia GutandLiverGroup,MurdochChildrensResearchInstitute,Parkville,VIC3052,Australia DepartmentofPaediatrics,UniversityofMelbourne,Melbourne,VIC3052,Australia CorrespondenceshouldbeaddressedtoAnthonyG.Catto-Smith,tony.cattosmith@.au Received25April2011;Revised10July2011;Accepted1October2011 AcademicEditor:PeterM.Irving Copyright?2011OliverGouldthorpeetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Crohn’sdiseasea?ectsincreasingnumbersofchildrenworldwide.Generally,childhood-onsetdiseaserunsamoreseverecourse thaninadultsandhasagreaterimpactonqualityoflife.Therapyinchildrenmusttakeaccountofadi?erentsetofrisksfor toxicitycomparedtoadults,butalsototheirlongevity.Biologicdrugspresentremarkableadvantagesintermsofdiseasecontrol forchildren,especiallyinthosewhosediseasecannotbecontrolledwithconventionaltherapies,buttheirlong-termrisksare stillbeingassessed.Dataregardingbiologicuseinchildrenislimitedandmostlyamountstocaseseries,butresultshavebeen promising,bothintermsofcontrollingdiseaseactivityandimprovinggrowthparameters.Adversereactionsareinfrequentinthe shortterm,butlossofresponseisalong-termproblem,particularlyinchildren.Moreinformationisneededaboutverylongterm risks.In?iximabandadalimumabarethemoststudiedagentsinchildren,whilethereisrelativelylimiteddataoncertolizumab andnatalizumab.Furthercollectionofdataontheseagentsisstillneeded,butthisshouldnotrestrictaccesstotheseagentsfor childreninwhomnootheragentise?ective. 1