Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer英文文献资料.docVIP

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Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer英文文献资料.doc

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Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer英文文献资料

HindawiPublishingCorporation AdvancesinUrology Volume2012,ArticleID781459,14pages doi:10.1155/2012/781459 ReviewArticle Biomarker-BasedTargetingoftheAndrogen-AndrogenReceptor AxisinAdvancedProstateCancer ManishKohli, RuiQin, RafaelJimenez, andScottM.Dehm 1 2 3 4 1 2 3 4 DepartmentofOncology,MayoClinic,200FirstStreetSW,Rochester,MN55905,USA DepartmentofHealthSciencesResearch,MayoClinic,200FirstStreetSW,Rochester,MN55905,USA DepartmentofLaboratoryMedicineandPathology,MayoClinic,200FirstStreetSW,Rochester,MN55905,USA MasonicCancerCenterandDepartmentofLaboratoryMedicineandPathology,UniversityofMinnesota,Minneapolis, MN55455,USA CorrespondenceshouldbeaddressedtoManishKohli,kohli.manish@ Received14April2012;Accepted9June2012 AcademicEditor:JoanneEdwards Copyright?2012ManishKohlietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Recenttherapeuticadvancesformanagingadvancedprostatecancerincludethesuccessfultargetingoftheandrogen-ARaxis withseveralnewdrugsincastrateresistantprostatecancerincludingabirateroneacetateandenzalutamide(MDV3100).This translational progress from “bench to bed-side” has resulted in an enlarging repertoire of novel and traditional drug choices nowavailableforuseinadvancedprostatecancertherapeutics,whichhashadapositiveclinicalimpactinprolonginglongevity and quality of life of advanced prostate cancer patients. In order to further the clinical utility of these drugs, development ofpredictivebiomarkersguidingindividualtherapeuticchoicesremainsanongoingchallenge.Thispaperwillsummarizethe potentialindevelopingpredictivebiomarkersbasedonthepathophysiologyoftheandrogen-ARaxisintumortissuefrompatients withadvancedprostatecanceraswellasinheritedvariationinthepatient’sgenome.Speci?cexamplesofrationalclinicaltrial designsincorporatingpotentialpredictivebiomarkersfromthesepathwa