Biomarkers and Depressive Symptoms in a Sample of Cognitively Intact and Alzheimer’s Disease Elderly Males英文文献资料.docVIP

Neuroscience Medicine, 2011, 2, 306-312 doi:10.4236/nm.2011.24040 Published Online December 2011 (http://www.SciRP.org/journal/nm) Biomarkers and Depressive Symptoms in a Sample of Cognitively Intact and Alzheimer’s Disease Elderly Males James R. Hall 1,2* , Hoa T. Vo , Leigh A. Johnson , Scott Winter , Robert C. Barber , 1 3 1 2,4 Sid E. O’Bryant 5,6 1 Department of Psychiatry and Neuroscience, University of North Texas Health Sciences Center, Fort Worth, USA; Aging and Alzheimer’s Disease Research, University of North Texas Health Sciences Center, Fort Worth, USA; Texas Tech Uni- versity Health Sciences Center, Laura W. Bush Institute for Women’s Health Department of Family and Community Medicine, Lubbock, USA; Department of Pharmacology and Neuroscience, University of North Texas Health Sciences Center, Fort Worth, F. Marie Hall Institute for Rural Community Health, Texas Tech Health Sciences Center, Lubbock, USA; Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, USA. 2 Institute for 3 4 USA; 5 6 E-mail: james.hall@ * Received October 6 , 2011; revised November 18 , 2011; accepted November 26 , 2011. th th th ABSTRACT Serum-based biomarkers and GDS-30 score and subscales of depressive symptoms were examined in a cross-sectional sample of 81 elderly men drawn from the TARCC cohort. Measurements included neuropsychological assessment and serum. Thirty three patients met consensus diagnosis for probable AD and forty eight were cognitively intact. Although initial regression analysis of all subjects showed significant relationships between depression and specific biomarkers, analyses based on diagnosis indicated