Biomarker Discovery of Pancreatic and Gastrointestinal Cancer by 2DICAL 2-Dimensional Image-Converted Analysis of Liquid Chromatography and Mass Spectrometry英文文献资料.docVIP

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Biomarker Discovery of Pancreatic and Gastrointestinal Cancer by 2DICAL 2-Dimensional Image-Converted Analysis of Liquid Chromatography and Mass Spectrometry英文文献资料.doc

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Biomarker Discovery of Pancreatic and Gastrointestinal Cancer by 2DICAL 2-Dimensional Image-Converted Analysis of Liquid Chromatography and Mass Spectrometry英文文献资料

HindawiPublishingCorporation InternationalJournalofProteomics Volume2012,ArticleID897412,10pages doi:10.1155/2012/897412 ReviewArticle BiomarkerDiscoveryofPancreaticandGastrointestinal Cancerby2DICAL:2-DimensionalImage-ConvertedAnalysisof LiquidChromatographyandMassSpectrometry MasayaOno, 1 MasahiroKamita, BannoMiho, 1 YusukeMurakoshi, TomohiroSakuma, 2 JunichiMatsubara, 3 andTesshiYamada KazufumiHonda, 1 4 4 1 1 DivisionofChemotherapyandClinicalResearch,NationalCancerCenterResearchInstitute,5-1-1Tsukiji,Chuo-ku, Tokyo104-0045,Japan 2 3 ThirdDepartmentofSurgery,TokyoMedicalUniversity,6-7-1Nishi-shinjuku,Shinjuku-ku,Tokyo160-0023,Japan InstituteforStemCellBiologyandRegenerativeMedicine(ISCBRM)andStanfordCancerCenter,StanfordUniversity, 265CampusDrive,RoomG2015,Stanford,CA94305,USA 4 BioScienceDepartment,ResearchandDevelopmentCenter,MitsuiKnowledgeIndustryCo.,Ltd.,2-7-14Higashinakano,Nakano-Ku, Tokyo164-8555,Japan CorrespondenceshouldbeaddressedtoMasayaOno,masono@ncc.go.jp Received2March2012;Accepted18April2012 AcademicEditor:FumioNomura Copyright?2012MasayaOnoetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Biomarkerstestedbybloodsampleareofgreatusetocliniciansastheyprovideusefulinformationtoaidanearlyandaccurate diagnosis.Comprehensive“omics”studiesareexpectedtofacilitatetheidenti?cationofsuchnewbiomarkers,andmuchresearchis beingperformedinthisarea.Ourproteomicsanalysissystemof2-dimensionalimage-convertedanalysisofliquidchromatography andmassspectrometry(2DICAL)hassuccessfullyidenti?edseveralnewbloodbiomarkersfromtheclinicalbloodsamplesof pancreaticandcolorectalcancerpatients. 1.Introduction 2.BiomarkerDetection Proteomicstudiesarepowerfultoolsforidentifying useful newbiomarkers,andmuchresearchiscurrentlybeingper- formedinthisarea.However,thebloodproteomeisextraor- dinary di?cult to analyze because protein concentrations