Biological Properties of Ti-Nb-Zr-O Nanostructures Grown on Ti35Nb5Zr Alloy英文文献资料.docVIP

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Biological Properties of Ti-Nb-Zr-O Nanostructures Grown on Ti35Nb5Zr Alloy英文文献资料.doc

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Biological Properties of Ti-Nb-Zr-O Nanostructures Grown on Ti35Nb5Zr Alloy英文文献资料

HindawiPublishingCorporation JournalofNanomaterials Volume2012,ArticleID834042,7pages doi:10.1155/2012/834042 ResearchArticle BiologicalPropertiesofTi-Nb-Zr-ONanostructuresGrownon Ti35Nb5ZrAlloy ZhaohuiLi, CongqinNing, DongyanDing, HegangLiu, 1 2 1 1andLinHuang 1,2 1 InstituteofMicroelectronicMaterialsandTechnology,SchoolofMaterialsScienceandEngineering, ShanghaiJiaoTongUniversity,Shanghai200240,China 2 StateKeyLaboratoryofHighPerformanceCeramicsandSuper?neMicrostructure,ShanghaiInstituteofCeramics, ChineseAcademyofSciences,Shanghai200050,China CorrespondenceshouldbeaddressedtoDongyanDing,dyding@ Received25May2012;Accepted20August2012 AcademicEditor:CuiChunXiang Copyright?2012ZhaohuiLietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Surfacemodi?cationoflowmodulusimplantalloyswithoxidenanostructuresisoneoftheimportantwaystoachievefavorable biologicalbehaviors.Inthepresentwork,amorphousTi-Nb-Zr-Onanostructuresweregrownonapeak-agedTi35Nb5Zralloy through anodization. Biological properties of the Ti-Nb-Zr-O nanostructures were investigated through in vitro bioactivity testings,stemcellinteractions,anddrugreleaseexperiments.TheTi-Nb-Zr-Onanostructuresdemonstratedagoodcapability ofinducingapatiteformationafterimmersioninsimulatedbody?uids(SBFs).Drugdeliveryexperimentbasedongentamicin andtheTi-Nb-Zr-Onanostructuresindicatedthatahighdrugloadingcontentcouldresultinaprolongedreleaseprocessanda higherquantityofdrugresiduesintheoxidenanostructuresafterdrugrelease.Quickstemcelladhesionandspreading,aswell asfastformationofextracellularmatrixmaterialsonthesurfacesoftheTi-Nb-Zr-Onanostructures,werefound.These?ndings makeitpossibletofurtherexplorethebiomedicalapplicationsoftheTi-Nb-Zr-Onanostructuremodi?edalloysespeciallyclinical operationoforthopaedicsbyutilizingthenanostructures-baseddrug-releas