Biomarkers of Subclinical Atherosclerosis in Patients with Autoimmune Disorders英文文献资料.docVIP

Biomarkers of Subclinical Atherosclerosis in Patients with Autoimmune Disorders英文文献资料.doc

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Biomarkers of Subclinical Atherosclerosis in Patients with Autoimmune Disorders英文文献资料

HindawiPublishingCorporation MediatorsofIn?ammation Volume2012,ArticleID503942,8pages doi:10.1155/2012/503942 ClinicalStudy BiomarkersofSubclinicalAtherosclerosisinPatientswith AutoimmuneDisorders ElisabettaProfumo, ManuelaDiFranco, CarmelinaFilesi, MariaElenaTosti, RossanaScrivo, AntonioSpadaro, LucianoSaso, andRacheleRigano` 1 1 2 BrigittaButtari, RobertaMasella, 1 3 AntongiulioScarno, 2 3 4 2 2 5 1 2 3 4 5 DipartimentodiMalattieInfettive,ParassitarieedImmunomediate,IstitutoSuperiorediSanit`a,00161Rome,Italy DipartimentodiMedicinaInternaeSpecialit`aMediche,Reumatologia,SapienzaUniversit`adiRoma,00185Rome,Italy DipartimentodiSanit`aPubblicaVeterinariaeSicurezzaAlimentare,IstitutoSuperiorediSanit`a,00161Rome,Italy CentroNazionalediEpidemiologia,SorveglianzaePromozionedellaSalute,IstitutoSuperiorediSanit`a,00161Rome,Italy DipartimentodiFisiologiaeFarmacologia“VittorioErspamer”,SapienzaUniversit`adiRoma,00185Rome,Italy CorrespondenceshouldbeaddressedtoRacheleRigano`,rachele.rigano@iss.it Received26July2011;Revised27October2011;Accepted18November2011 AcademicEditor:MuzamilAhmad Copyright?2012ElisabettaProfumoetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Atherosclerosisisacceleratedinrheumatoidarthritis(RA)andpsoriaticarthritis(PsA).Weinvestigatedapossibleassociation ofoxidizedlow-densitylipoproteins(ox-LDLs),nitricoxide(NO),3-nitrotyrosine,vitaminA,vitaminE,andβ-caroteneserum levelswithsubclinicalatherosclerosisinRAandPsA.BytheuseofELISA,weobservedhigherox-LDLlevelsinpatientswith intima-mediathickness(IMT)1thaninpatientswithIMT≤1andanegativecorrelationbetweenNOlevelsandIMTvalues. Bytheuseofhigh-performanceliquidchromatography,wedeterminedhigherlevelsofvitaminAinpatientswithPsAandIMT ≤1thanincontrolsandlowerlevelsofβ-caroteneinpatientswithRAandPsAthanincontrols.β-caroteneconcentrationswere negativelycorrel

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