Biomarkers of Subclinical Atherosclerosis in Patients with Autoimmune Disorders英文文献资料.docVIP
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Biomarkers of Subclinical Atherosclerosis in Patients with Autoimmune Disorders英文文献资料
HindawiPublishingCorporation
MediatorsofIn?ammation
Volume2012,ArticleID503942,8pages
doi:10.1155/2012/503942
ClinicalStudy
BiomarkersofSubclinicalAtherosclerosisinPatientswith
AutoimmuneDisorders
ElisabettaProfumo, ManuelaDiFranco,
CarmelinaFilesi, MariaElenaTosti, RossanaScrivo,
AntonioSpadaro, LucianoSaso,
andRacheleRigano`
1
1
2
BrigittaButtari, RobertaMasella,
1 3
AntongiulioScarno,
2
3
4
2
2
5
1
2
3
4
5
DipartimentodiMalattieInfettive,ParassitarieedImmunomediate,IstitutoSuperiorediSanit`a,00161Rome,Italy
DipartimentodiMedicinaInternaeSpecialit`aMediche,Reumatologia,SapienzaUniversit`adiRoma,00185Rome,Italy
DipartimentodiSanit`aPubblicaVeterinariaeSicurezzaAlimentare,IstitutoSuperiorediSanit`a,00161Rome,Italy
CentroNazionalediEpidemiologia,SorveglianzaePromozionedellaSalute,IstitutoSuperiorediSanit`a,00161Rome,Italy
DipartimentodiFisiologiaeFarmacologia“VittorioErspamer”,SapienzaUniversit`adiRoma,00185Rome,Italy
CorrespondenceshouldbeaddressedtoRacheleRigano`,rachele.rigano@iss.it
Received26July2011;Revised27October2011;Accepted18November2011
AcademicEditor:MuzamilAhmad
Copyright?2012ElisabettaProfumoetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution
License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly
cited.
Atherosclerosisisacceleratedinrheumatoidarthritis(RA)andpsoriaticarthritis(PsA).Weinvestigatedapossibleassociation
ofoxidizedlow-densitylipoproteins(ox-LDLs),nitricoxide(NO),3-nitrotyrosine,vitaminA,vitaminE,andβ-caroteneserum
levelswithsubclinicalatherosclerosisinRAandPsA.BytheuseofELISA,weobservedhigherox-LDLlevelsinpatientswith
intima-mediathickness(IMT)1thaninpatientswithIMT≤1andanegativecorrelationbetweenNOlevelsandIMTvalues.
Bytheuseofhigh-performanceliquidchromatography,wedeterminedhigherlevelsofvitaminAinpatientswithPsAandIMT
≤1thanincontrolsandlowerlevelsofβ-caroteneinpatientswithRAandPsAthanincontrols.β-caroteneconcentrationswere
negativelycorrel
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