Bird’s Eye View on the Recent Advances in Drug Delivery Systems英文文献资料.docVIP

Journal of Biomaterials and Nanobiotechnology, 2011, 2, 544-556 doi:10.4236/jbnb.2011.225065 Published Online December 2011 (/journal/jbnb) Bird’s Eye View on the Recent Advances in Drug Delivery Systems Pramod Vishwanath Prasad 1* , Anand Kumar 2 , Pramod Chandra Pal 3 , Radhey Shyam Sharma 4 , Donthamsetty Nageswara Rao 3 , Tulsidas G. Shrivastav 5 , Ren-Shan Ge 1 1 Center for Biomedical Research, Population Council, The Rockefeller University, New York, USA; Biology, All India Institute of Medical Sciences, New Delhi, India; Department of Biochemistry, All India Institute of Medical Sci- ences, New Delhi, India; Division of RHN, Indian Council of Medical Research, New Delhi, India; Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, New Delhi, India. 2 Department of Reproductive 3 4 5 E-mail: drpramod.pusa@, pkbiochem@ * * Received September 5 , 2011; revised October 14 , 2011; accepted November 20 , 2011. th th th ABSTRACT Successful treatment of most of the diseases is limited by a lack of safe and effective methods of drug delivery. Drug delivery methods have significant effects on the pharmacological efficacy of a drug. Every drug has an optimum con- centration range within which maximum benefit is derived; and concentrations above or below the range can be toxic or provide no therapeutic benefits at all. Therefore, development of an efficient drug delivery system remains an im- portant challenge in medicine, and this can be achieved only through multidisciplinary approaches to the mechanisms of delivery of drugs to targets in tissues. Thus, several drug delivery and drug targeting systems are currently being developed. Targeting is an ability to direct the drug(