Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice英文文献资料.docVIP

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Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice英文文献资料.doc

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Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice英文文献资料

HindawiPublishingCorporation ClinicalandDevelopmentalImmunology Volume2012,ArticleID842928,11pages doi:10.1155/2012/842928 ResearchArticle Bene?cialEffectofBupleurumPolysaccharideson Autoimmune-ProneMRL-lprMice Yi-WenJiang, HongLi, Yun-YiZhang, WenLi, Yi-FanJiang, 1 1 1 1 1 Ying-YeOu, andDao-FengChen 2 1 1 2 DepartmentofPharmacology,SchoolofPharmacy,FudanUniversity,826ZhanghengRoad,PudongDistrict,Shanghai201203,China DepartmentofPharmacognosy,SchoolofPharmacy,FudanUniversity,826ZhanghengRoad,PudongDistrict, Shanghai201203,China CorrespondenceshouldbeaddressedtoHongLi,lxzhang@andDao-FengChen,dfchen@ Received4January2012;Revised28February2012;Accepted10April2012 AcademicEditor:AnneDavidson Copyright?2012Yi-WenJiangetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Systemiclupuserythematosus(SLE)isachronicsystemicautoimmunediseaseleadingtoin?ammatorytissuedamageinmultiple organs.Thecrudepolysaccharides(BPs)isolatedfromtherootsofBupleurumsmithiivar.parvifoliumhaveanticomplementary activityandimmunomodulatoryfunctionsonmacrophages.Tostudyitspotentialbene?tonSLE,weexaminede?ectsofBPson MRL-lprmice,whichhavesimilardiseasefeaturestohumanSLE.MRL-lprmiceweretreatedorallywithBPs15,30,or60mg ?1 ?1for12weeksandtheirSLEcharacteristicswereevaluated.TheresultsrevealedthatBPselongatedlifespan,improved kg day kidneyfunction,delayedlymphadenopathy,andreducedautoantibodies.Itseemedtobemediatedbyinhibitionofcomplement andmacrophagesactivationandsuppressionofinterferon-γ(IFN-γ)andinterleukin-6(IL-6)geneexpressioninthekidney.These resultsimplicatethatBPsmaybeanimmunomodulatorforthetreatmentofautoimmunediseaseslikeSLE. 1.Introduction SLE.Depositionofimmunecomplexinthekidneytriggers theproductionofproin?ammatorymediators,resultingin macrophage and lymphocyte in?ltration, and ultimately to glomeruloscl