Cancer Stem Cells and Epithelial Ovarian Cancer英文文献资料.docVIP

HindawiPublishingCorporation JournalofOncology Volume2010,ArticleID105269,9pages doi:10.1155/2010/105269 ReviewArticle CancerStemCellsandEpithelialOvarianCancer SheetalDyall, SimonA.Gayther, 1 1andDimitraDafou 1,2 1 2 GynaecologicalCancerResearchLaboratory,EGAUCLInstituteforWomen’sHealth,LondonWC1E6DD,UK King’sCollegeSchoolofMedicine,Guy’sHospital,LondonSE19RT,UK CorrespondenceshouldbeaddressedtoSheetalDyall,s.dyall@ucl.ac.uk Received15June2010;Accepted9November2010 AcademicEditor:PeterE.Schwartz Copyright?2010SheetalDyalletal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Thecancerstemcellhypothesisisbecomingmorewidelyacceptedasamodelforcarcinogenesis.Tumoursareheterogeneous both at the molecular and cellular level, containing a small population of cells that possess highly tumourigenic “stem-cell” properties.Cancerstemcells(CSCs),ortumour-initiatingcells,havetheabilitytoself-renew,generatexenograftsreminiscent oftheprimarytumourthattheywerederivedfrom,andarechemoresistant.ThecharacterisationoftheCSCpopulationwithin a tumour that drives its growth could provide novel target therapeutics against these cells speci?cally, eradicating the cancer completely.Therehavebeenseveralreportsdescribingtheisolationofputativecancerstemcellpopulationsinseveralcancers; however,node?nedsetofmarkershasbeenidenti?edthatconclusivelycharacterises“stem-like”cancercells.Thispaperhighlights thecurrentexperimentalapproachesthathavebeenusedinthe?eldanddiscussestheirlimitations,withspeci?cemphasisonthe identi?cationandcharacterisationoftheCSCpopulationinepithelialovariancancer. 1.Introduction representsuitabletargetsfornewtherapeuticapproachesfor epithelialovariancancers(EOC). Ovarian cancer (OC) is the sixth most lethal malignancy in women in the western world. Over 90% of malignant tumoursareepithelial.Ithasbeenhypothesisedthattumou