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Cancer Vaccine by Fusions of Dendritic and Cancer Cells英文文献资料.doc

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Cancer Vaccine by Fusions of Dendritic and Cancer Cells英文文献资料

HindawiPublishingCorporation ClinicalandDevelopmentalImmunology Volume2009,ArticleID657369,13pages doi:10.1155/2009/657369 ReviewArticle CancerVaccinebyFusionsofDendriticandCancerCells ShigeoKoido,1,2,3EiichiHara, 4 SadamuHomma, YoshihisaNamiki, 5 3 2 ToshifumiOhkusa, 1 JianlinGong, andHisaoTajiri 1 1 DivisionofGastroenterologyandHepatology,DepartmentofInternalMedicine,TheJikeiUniversitySchoolofMedicine, Tokyo277-8567,Japan 2 3 4 5 InstituteofClinicalMedicineandResearch,TheJikeiUniversitySchoolofMedicine,Tokyo277-8567,Japan DepartmentofOncology,InstituteofDNAMedicine,TheJikeiUniversitySchoolofMedicine,Tokyo277-8567,Japan SaitamaCancerCenterResearchInstituteforClinicalOncology,Saitama277-8567,Japan DepartmentofMedicine,BostonUniversitySchoolofMedicine,Boston,MA02118,USA CorrespondenceshouldbeaddressedtoShigeoKoido,shigeokoido@jikei.ac.jp Received17October2009;Accepted9December2009 RecommendedbyMarioClerici Dendriticcells(DCs)arepotentantigen-presentingcellsandplayacentralroleintheinitiationandregulationofprimaryimmune responses.Therefore,theirusefortheactiveimmunotherapyagainstcancershasbeenstudiedwithconsiderableinterest.The fusionofDCswithwholetumorcellsrepresentsinmanywaysanidealapproachtodeliver,process,andsubsequentlypresent abroadarrayoftumor-associatedantigens,includingthoseyettobeunidenti?ed,inthecontextofDCs-derivedcostimulatory molecules.DCs/tumorfusionvaccinestimulatespotentantitumorimmunityintheanimaltumormodels.Inthehumanstudies, TcellsstimulatedbyDC/tumorfusioncellsaree?ectiveinlysisoftumorcellsthatareusedasthefusionpartner.Intheclinical trials, clinical and immunological responses were observed in patients with advanced stage of malignant tumors after being vaccinatedwithDC/tumorfusioncells,althoughtheantitumore?ectisnotasvigorousasintheanimaltumormodels.This reviewsummarizesrecentadvancesinconceptsandtechniquesthatareprovidingnewimpulsestoDCs/tumorfusions-based cancervaccination. Copyright?2009ShigeoKoidoetal.Thisisanopenaccessart