Cardiac Conduction Safety during Coadministration of Artemether-Lumefantrine and LopinavirRitonavir in HIV-Infected Ugandan Adults英文文献资料.docVIP

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Cardiac Conduction Safety during Coadministration of Artemether-Lumefantrine and LopinavirRitonavir in HIV-Infected Ugandan Adults英文文献资料.doc

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Cardiac Conduction Safety during Coadministration of Artemether-Lumefantrine and LopinavirRitonavir in HIV-Infected Ugandan Adults英文文献资料

HindawiPublishingCorporation ChemotherapyResearchandPractice Volume2011,ArticleID393976,4pages doi:10.1155/2011/393976 ResearchArticle CardiacConductionSafetyduringCoadministrationof Artemether-LumefantrineandLopinavir/Ritonavirin HIV-InfectedUgandanAdults WilsonB.Nyakoojo, PaulineByakika-Kibwika,1,2,3MohammedLamorde,1,2PeterLwabi,4 4 HarrietMayanja-Kizza,1,3MartaBof?to, EllyKatabira, 1,3 andConceptaMerry1,2,3 VioletOkaba-Kayom, 1 5 DavidBack, SayeKhoo, 6 6 1 2 3 4 5 6 InfectiousDiseasesInstitute,MakerereUniversity,P.O.Box22418,Kampala,Uganda TrinityCollege,Dublin2,Ireland InfectiousDiseasesNetworkforTreatmentandResearchinAfrica(INTERACT),P.O.Box7062,Kampala,Uganda UgandaHeartInstitute,MulagoHospital,P.OBox7051,Kampala,Uganda St.Stephen’sAIDSTrust,LondonSW109TR,UK UniversityofLiverpool,LiverpoolL693BX,UK CorrespondenceshouldbeaddressedtoPaulineByakika-Kibwika,pbyakika@ Received31August2010;Revised26November2010;Accepted14February2011 AcademicEditor:KazuoTamura Copyright?2011PaulineByakika-Kibwikaetal. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. Background.WeaimedtoassesscardiacconductionsafetyofcoadministrationoftheCYP3A4inhibitorlopinavir/ritonavir(LPV/r) andtheCYP3A4substrateartemether-lumefantrine(AL)inHIV-positiveUgandans.Methods.Open-labelsafetystudyofHIV- positiveadults administered single-doseAL (80/400mg) aloneorwith LPV/r(400/100mg).Cardiacfunction wasmonitored usingcontinuouselectrocardiograph(ECG).Results.Thirty-twopatientswereenrolled;16takingLPV/r-basedARTand16ART na¨?ve.AlltooksingledoseAL.Noseriousadverseeventswereobserved.ECGparametersinmillisecondsremainedwithinnormal limits.QTcmeasurementsdidnotchangesigni?cantlyover72hoursalthoughwerehigherinLPV/rarmat24(424versus406; P =.02)and72hours(424versus408;P =.004)afterALintake.Conclusion.Coadministrationofsin