Cardio-Toxicity during chemotherapy feasibility of new diagnostic approaches英文文献资料.docVIP

Vol.2, No.4, 376-380 (2010) Health doi:10.4236/health.2010.24056 Cardio-Toxicity during chemotherapy: feasibility of new diagnostic approaches Fable Zustovich 1 , Mario Trivellato , Renato Ceravolo , Davide Pastorelli Lorena Buratin , Monica Mion , Martina Zaninotto , Martina Mattiazzi , Mario Plebani 2 3 3 1 Giuseppe Cartei 1 2 1 1 , Rosanna Canton 2 , , 3 1 2 3 Oncologia Medica 1° piano, IOV – IRCCS, Padova, Italy; fable.zustovich@ioveneto.it Servizio di Cardiologia ULSS16 c/o IRA, Padova, Italy Dipartimento di Medicina di Laboratorio, Università – Azienda Ospedaliera, Padova, Italy Received 25 October 2009; revised 28 November 2009; accepted 5 December 2009. ABSTRACT The evaluation of the cardiac safety during cardio toxic chemotherapy is usually based on standard EKG, EKG Holter and mostly using echo-color doppler car- diography. All these methods reveal cardiac damage when macroscopic morphological alterations have been reached, thus when damage is already present and often irreversible. New methods of investigation are needed in attempt to detect a subclinical damage and to prevent the symptomatic cardiac failure. We evaluated the feasibility of some new techniques planning prospective preliminary studies monitoring patients undergoing potentially cardio toxic chemotherapy with 12-diagnostic leads EKG telemetry (TDLT), 7 days EKG monitoring device (R-Test Evolution Chemotherapy induced cardio-toxicity is a well known side effect of anticancer treatments, moreover the 70% of all tumors involve patients over 65 years-old, frequently with cardiac co- morbidity. We evaluated the feasibility of the application during chemotherapy administration of some of the most recent diagnostic tech- niques as 12-diagnostic