Cardiorenal Effects of Newer NSAIDs (Celecoxib) versus Classic NSAIDs (Ibuprofen) in Patients with Arthritis英文文献资料.docVIP

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Cardiorenal Effects of Newer NSAIDs (Celecoxib) versus Classic NSAIDs (Ibuprofen) in Patients with Arthritis英文文献资料.doc

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Cardiorenal Effects of Newer NSAIDs (Celecoxib) versus Classic NSAIDs (Ibuprofen) in Patients with Arthritis英文文献资料

HindawiPublishingCorporation JournalofToxicology Volume2011,ArticleID862153,8pages doi:10.1155/2011/862153 ResearchArticle CardiorenalEffectsofNewerNSAIDs(Celecoxib)versusClassic NSAIDs(Ibuprofen)inPatientswithArthritis RagiaHegazy,1,2MohamedAlashhab,3andMadihaAmin 4,5 1 2 3 4 5 DepartmentofForensicMedicineandClinicalToxicology,BenhaFacultyofMedicine,BenhaUniversity,Benha,Egypt DepartmentofPharamacologyandToxicology,FacultyofPharmacy,UmmAl-QuraUniversity(UQU),Mecca,SaudiArabia DepartmentofOrthopedics,BenhaFacultyofMedicine,BenhaUniversity,Benha,Egypt DepartmentofPharmacognocy,AlexandriaFacultyofPharmacy,AlexandriaUniversity,Alexandria,Egypt DepartmentofPharmacognocy,FacultyofPharmacy,UmmAl-QuraUniversity(UQU),Mecca,SaudiArabia CorrespondenceshouldbeaddressedtoRagiaHegazy,rmhegazy@.sa Received22November2010;Revised10March2011;Accepted16March2011 AcademicEditor:P.J.O’Brien Copyright?2011RagiaHegazyetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Background. Arthritis is a common condition that co-exists in the elderly population. This condition leads to frequent administrationofcomorbidanalgesicsespeciallynonsteroidalanti-in?ammatorydrugs (NSAIDs).Aim.Tostudycardiorenal toxicity of celecoxib versus ibuprofen in arthritic patients. Subjects and Methods. Seven hundred ninety-wo arthritic patients were enrolled in the study for 6 months. Three hundred ninety-six patients administered celecoxib 400mg twice a day; 396 patientsadministeredibuprofen300mgthreetimesaday.E?ectsmeasuredincludedinvestigator-reportedhypertension,edema, or congestive heart failure, increases in serum creatinine or reduction in serum creatinine clearance, and changes in serum electrolytes.Results.Celecoxibwasassociatedwithsigni?cant(P.05)lowerincidenceofhypertensionandedemaincomparison with ibuprofen. Systolic hypertension occurred signi?cantly less (P