Cardiovascular Activity of Labdane Diterpenes from Andrographis paniculata in Isolated Rat Hearts英文文献资料.docVIP

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2012,ArticleID876458,5pages doi:10.1155/2012/876458 ResearchArticle CardiovascularActivityofLabdaneDiterpenesfrom AndrographispaniculatainIsolatedRatHearts KhalijahAwang, NorHayatiAbdullah, A.HamidA.Hadi, andYewSuFong 1 2 1 3 1 2 3 DepartmentofChemistry,FacultyofScience,UniversityofMalaya,50603KualaLumpur,Malaysia MedicinalPlantsDivision,ForestResearchInstituteofMalaysia(FRIM),Kepong,52109KualaLumpur,Malaysia DepartmentofPharmacy,FacultyofAlliedHealthSciences,UniversitiKebangsaanMalaysia,50300KualaLumpur,Malaysia CorrespondenceshouldbeaddressedtoKhalijahAwang,khalijah@.my Received29July2011;Revised20January2012;Accepted21January2012 AcademicEditor:Masa-AkiShibata Copyright?2012KhalijahAwangetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract signi?cantly reduced coronary perfusion pressure by up to 24.5± 3.0mmHg at a 3mg dose and also reduced heart rate by upto49.5± 11.4beats/minuteatthisdose.Fivelabdanediterpenes,14-deoxy-12-hydroxyandrographolide(1 ),14-deoxy-11,12- didehydroandrographolide(2),14-deoxyandrographolide(3),andrographolide(4),andneoandrographolide(5),wereisolated fromtheaerialpartsofthismedicinalplant.Bioassay-guidedstudiesusinganimalmodelshowedthatcompounds,(2)and(3) wereresponsibleforthecoronaryvasodilatation.Thisstudyalsoshowedthatandrographolide(4),themajorlabdanediterpenein thisplant,hasminimale?ectsontheheart. 1.Introduction suppressvariouscancercells[16–18],andantifertility and pregnancy-terminatinge?ects[19]. AndrographispaniculataNees,familyAcanthaceae,hasbeen usedsincetimeimmemorialinAyurvedicmedicine,mainly forliverproblemsanddysentery[1]