Cardiovascular Disease in Rheumatoid Arthritis A Systematic Literature Review in Latin America英文文献资料.docVIP
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Cardiovascular Disease in Rheumatoid Arthritis A Systematic Literature Review in Latin America英文文献资料
HindawiPublishingCorporation
Arthritis
Volume2012,ArticleID371909,17pages
doi:10.1155/2012/371909
ReviewArticle
CardiovascularDiseaseinRheumatoidArthritis:
ASystematicLiteratureReviewinLatinAmerica
JuanCamiloSarmiento-Monroy,JennyAmaya-Amaya,JuanSebasti′anEspinosa-Serna,
CatalinaHerrera-D′?az,Juan-ManuelAnaya,andAdrianaRojas-Villarraga
CenterforAutoimmuneDiseasesResearch(CREA),SchoolofMedicineandHealthSciences,
UniversidaddelRosario,111221Bogot′a,Colombia
CorrespondenceshouldbeaddressedtoAdrianaRojas-Villarraga,samanda.rojas@.co
Received31July2012;Accepted27August2012
AcademicEditor:ClaudioGalarza-Maldonado
Copyright?2012JuanCamiloSarmiento-Monroyetal.ThisisanopenaccessarticledistributedundertheCreativeCommons
AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis
properlycited.
Background.Cardiovasculardisease(CVD)isthemajorpredictorofpoorprognosisinrheumatoidarthritis(RA)patients.There
isanincreasinginteresttoidentify“nontraditional”riskfactorsforthiscondition.LatinAmericans(LA)areconsideredasa
minoritysubpopulationandethnicallydi?erentduetoadmixturecharacteristics.Todate,therearenosystematicreviewsofthe
literaturepublishedinLAandtheCaribbeanaboutCVDinRApatients.Methods.Thesystematicliteraturereviewwasdoneby
twoblindedreviewerswhoindependentlyassessedstudiesforeligibility.ThesearchwascompletedthroughPubMed,LILACS,
SciELO,andVirtualHealthLibraryscienti?cdatabases.Results.Thesearchretrieved10,083potentialstudies.Atotalof16articles
concerningcardiovascularriskfactorsandmeasurementofanycardiovascularoutcomeinLAwereincluded.Theprevalenceof
CVDinLApatientswithRAwas35.3%.Non-traditionalriskfactorsassociatedtoCVDinthispopulationwereHLA-DRB1
sharedepitopealleles,rheumatoidfactor,markersofchronicin?ammation,longdurationofRA,steroids,familialautoimmunity,
andthrombogenicfactors.Conclusions.ThereislimiteddataaboutCVDandRAinLA.Weproposetoevaluatecardiovascularrisk
factorscomprehensivelyintheLatinRApatientandtogenerate
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