Cardiovascular Outcomes in Patients with Normal and Abnormal 24-Hour Ambulatory Blood Pressure Monitoring英文文献资料.docVIP

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Cardiovascular Outcomes in Patients with Normal and Abnormal 24-Hour Ambulatory Blood Pressure Monitoring英文文献资料.doc

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Cardiovascular Outcomes in Patients with Normal and Abnormal 24-Hour Ambulatory Blood Pressure Monitoring英文文献资料

SAGE-HindawiAccesstoResearch InternationalJournalofHypertension Volume2011,ArticleID786912,4pages doi:10.4061/2011/786912 ResearchArticle CardiovascularOutcomesinPatientswithNormalandAbnormal 24-HourAmbulatoryBloodPressureMonitoring P.IqbalandLouiseStevenson Chester?eldHypertensionClinic,Chester?eldRoyalHospitalNHSFoundationTrust,Chester?eldS445BL,UK CorrespondenceshouldbeaddressedtoP.Iqbal,drpi2pc@ Received11September2010;Accepted7November2010 AcademicEditor:SamyI.McFarlane Copyright?2011P.IqbalandL.Stevenson.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Introduction. 24-hour ambulatory blood pressure monitoring (ABPM) plays an important role in assessing cardiovascular prognosis,throughpresenceorabsenceofABPM-relatedprognosticfeatures.Objectives.Tostudyrelationshipbetween24-hour ABPMandcardiovascularoutcomesinpatientsfromChester?eldRoyalHospital.MaterialandMethods.Over12monthsfrom the 1st of August 2002, 1187 individuals had 24-hour ABPM performed. Cardiovascular outcomes were studied in a subset (297)oftheoriginalcohort,madeupbyevery4thconsecutivesubject.ThefollowingABPM-relatedprognosticfeatureswere studied—highdaytimesystolicanddiastolicBP(≥135,≥85mmHg),highnighttimesystolicanddiastolicBP(≥120mmHg, ≥75mmHg),absenceofnocturnaldip(≤10%fallinnighttimeSBP),highearlymorningSBP(≥140mmHg),andmorningsurge (≥20/15mmHg).ThecardiovascularoutcomesstudiedinthefourthtableincludedfatalandnonfatalMI,newdiagnosisofangina, acutecoronarysyndrome,suddencardiacdeath,cardiacarrhythmias,acuteLVF,cerbrovascularevents,peripheralvasculardisease, abdominalaorticaneurysm,andCKDstage3orabove.Results.Overafollowupperiodof2015± 116days(1720–2305days)82 cardiovasculareventsoccurredin61subjects.CardiacarrhythmiaswerethemostcommonCVoutcome(34events)followedby cerebrovascularevents(15).Statisticallysigni?cantassociationsfoundwerebetweencerebrovascu