CCL5RANTES Gene Polymorphisms in Slavonic Patients with Myocardial Infarction英文文献资料.docVIP

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CCL5RANTES Gene Polymorphisms in Slavonic Patients with Myocardial Infarction英文文献资料.doc

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CCL5RANTES Gene Polymorphisms in Slavonic Patients with Myocardial Infarction英文文献资料

HindawiPublishingCorporation MediatorsofIn?ammation Volume2011,ArticleID525691,6pages doi:10.1155/2011/525691 ClinicalStudy CCL5/RANTESGenePolymorphismsin SlavonicPatientswithMyocardialInfarction MilosTaborsky, IrinaP.Tereshchenko,1,2JanaPetrkova,1,3MikhailI.Voevoda,2 3 2 ZdenkaNavratilova, 1 AidaG.Romaschenko, andMartinPetrek 1,4 2 VladimirN.Maksimov, FrantisekMrazek, 1 1 LaboratoryofImmunogenomicsandProteomics,InstituteofMolecularandTranslationalMedicine, PalackyUniversityandFacultyHospital,77520Olomouc,CzechRepublic 2 3 4 InstituteofInternalMedicine,SiberianBranchofRussianAcademyofMedicalSciences,Novosibirsk630089,Russia InternalMedicine—Cardiology,PalackyUniversityandFacultyHospital,77520Olomouc,CzechRepublic CardiogeneticsandImmunogeneticsLaboratory,PalackyUniversityandFacultyHospital,77520Olomouc,CzechRepublic CorrespondenceshouldbeaddressedtoIrinaP.Tereshchenko,tereshchenko ip@mail.ruandJanaPetrkova,jana.petrkova@fnol.cz Received30November2010;Accepted27January2011 AcademicEditor:Y.Mandi Copyright?2011IrinaP.Tereshchenkoetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Coronary artery in?ammation is a critical process in the pathogenesis of myocardial infarction (MI). The chemokine CCL5/RANTES(regulateduponactivation,normalTcellsexpressedandsecreted)isexpressedinadvancedatheroscleroticlesions. FunctionalpolymorphismsoftheRANTESgenecan,therefore,beinvolvedinthepathogenesisofcoronaryarterydisease.We examinedtheassociationofpolymorphismsintheRANTESgenewithmyocardialinfarctioninSlavonicpopulationsofCzech andRussianorigin.Atotalof467post-MIpatientsand337controlsubjects weregenotypedforRANTESpromoterG-403A (rs2107538)andintron1.1T/C(rs2280789)variantsbyPCR-SSP.BothRANTESgenotypesandallelefrequenciesdidnotdi?er between case and control groups. Haplotype-based analysis also failed to reveal an ass