CD36 Is Significantly Correlated with Adipophilin in Human Carotid Lesions and Inversely Correlated with Plasma ApoAI英文文献资料.docVIP

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CD36 Is Significantly Correlated with Adipophilin in Human Carotid Lesions and Inversely Correlated with Plasma ApoAI英文文献资料.doc

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CD36 Is Significantly Correlated with Adipophilin in Human Carotid Lesions and Inversely Correlated with Plasma ApoAI英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2008,ArticleID813236,8pages doi:10.1155/2008/813236 ResearchArticle CD36IsSigni?cantlyCorrelatedwithAdipophilininHuman CarotidLesionsandInverselyCorrelatedwithPlasmaApoAI SophieCollot-Teixeira,1,2CalypsoBarbatis,3FlorenceBultelle,2MichaelKoutouzis,3 GerardPasterkamp,4PaulFraser,1ZenonS.Kyriakides,3RobinN.Poston,1AngeliqueRistagno,2 LilianMcGregor,5ChantalM.Boulanger,6GuyLeseche,7andJohnL.McGregor1,2,6 1 CardiovascularDivision,King’sCollegeLondon,UniversityofLondon,Franklin-WilkinsBuilding,150StamfordStreet, LondonSE19NH,UK 2 3 4 5 6 7 GenomicsandAtherothrombosisLaboratory,ThrombosisResearchInstitute,LondonSW36LR,UK DepartmentofPathology,HelenicRedCrossHospital,Athens,Greece LaboratoryofExperimentalCardiology,UtrechtUniversityHospital,Heidelberglaan100,3584CXUtrecht,TheNetherlands EA3470/INSERMIFR63,FacultyofMedicineRTHLaennec,ClaudeBernard-Lyon1University,69372LyonCedex08,France INSERMU689,CentredeRechercheCardiovasculaire,H?opitalLariboisi`ere,75010Paris,France VascularSurgeryDepartment,BichatHospital,75018Paris,France CorrespondenceshouldbeaddressedtoSophieCollot-Teixeira,sophie.collot@kcl.ac.uk Received8April2008;Revised18June2008;Accepted29July2008 RecommendedbyMohamedBoutjdir OxLDLuptakeandcholesterole?uxinhibitioninmacrophagesplayakeyroleinatheroscleroticplaqueformation,rupture, andthromboticischemia.ThisstudyinvestigatesgenesimplicatedinOxLDLuptake(CD36,SRA),cholesterole?uxinhibition (adipophilin,ADFP),andin?ammatoryrecruitmentsofleukocytes(IL-8)inplaquelesionareas(PLAs)comparedtononplaque lesionareas(NPLAs)inhumancarotidendarterectomyspecimens.Geneandproteinexpressionswereassayedusingquantitative PCRandquantitativeimmunohistochemistry.Pearsontestswereusedtoinvestigatepotentialcorrelationbetween(a)di?erent gene expressions and (b) gene expression and patient’s plasma constituents. CD36, SRA, ADFP, and IL-8 were shown to be signi?cantlymoreexpressedinPLAcomparedtoNPLA.InPLA,asigni?cantco