CD38 expression on CD8+ cells—Its influence on development of tuberculosis in HIV positive individuals英文文献资料.docVIP

Vol.2, No.2, 65-71 (2012) Open Journal of Immunology /10.4236/oji.2012.22008 CD38 expression on CD8+ cells—Its influence on development of tuberculosis in HIV positive individuals Ramaseri Sunder Sharada , Hanumanth Surekha Rani , Satya Sudheer Pydi , 1 2 1 1* 1 Jonnalagada Subbanna , Vijaya lakshmi Valluri 1 * 2 Immunology and Molecular Biology Division, LEPRA India-Blue Peter Public Health Research Centre, Hyderabad, India; Corresponding Author: vijayavalluri@ Department of Genetics, Osmania University, Hyderabad, India Received 14 February 2012; revised 20 March 2012; accepted 5 April 2012 ABSTRACT liferative response to HIV-specific antigen is well estab- lished in long-term non-progressors than those with more rapid progression [2]. CD38 expression on CD8+ cells seems to cor- relate well with HIV viral-loads, while the ex- pression levels are thought to be low in patients with tuberculosis. This study aimed at deter- mining the levels of CD38 expression in HIV+ individuals who develop tuberculosis. Expres- sion levels of CD8 and CD38 were analysed in peripheral blood collected from HIV (73), TB (32), HIV-TB (31) and healthy controls (20). The per- centage of CD8+/CD38+ cells significantly in- creased during the first few years of seroposi- tivity and decreased during 5 - 6 years. A decline in the expression of CD38, especially on CD8+ cells in a HIV+ individual within first 2 years of seropositivity, may be indicative of susceptibil- ity to tuberculosis. This observation was reiter- ated when two patients developed TB during follow-up. CD38 on CD8 cells could perhaps be useful as an early biomarker for tuberculosis in HIV-positive individuals. It is well-known that CD4+ cells decline during infec- tion with HIV and the numbers reduce further with dis- ease p