CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells 200？CellμL The DART Trial STI Substudy英文文献资料.docVIP

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CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells 200？CellμL The DART Trial STI Substudy英文文献资料.doc

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CD8T-CellResponsesbeforeandafterStructuredTreatmentInterruptioninUgandanAdultsWhoInitiatedARTwithCD4TCells200？CellμLTheDARTTrialSTISubstudy英文文献资料

HindawiPublishingCorporation AIDSResearchandTreatment Volume2011,ArticleID875028,10pages doi:10.1155/2011/875028 ResearchArticle CD8+T-CellResponsesbeforeandafterStructuredTreatment InterruptioninUgandanAdultsWhoInitiatedARTwithCD4+T Cells200Cell/μL:TheDARTTrialSTISubstudy JenniferSerwanga, 2 1 SusanMugaba, 1 1 AumaBetty, EdwardPimego, 1 1 FrancesGotch, 4 SarahWalker, PaulaMunderi, CharlesGilks, 3 HeinerGrosskurth,1,5andPontianoKaleebu 1 1 2 3 4 5 MRC/UVRIUgandaResearchUnitonAIDS,51-59NakiwogoRoad,Entebbe,Uganda MRCClinicalTrialsUnit,222EustonRoad,LondonNW12DA,UK ImperialCollegeLondon,SouthKensingtonCampus,LondonSW72AZ,UK DepartmentofImmunology,ImperialCollege,ChelseaandWestminsterHospital,LondonSW109NH,UK LondonSchoolofHygieneTropicalMedicine,UniversityofLondon,LondonWC1E7HT,UK CorrespondenceshouldbeaddressedtoJenniferSerwanga,jennifer.serwanga@ Received27May2010;Accepted15December2010 AcademicEditor:JoepLange Copyright?2011JenniferSerwangaetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Objective.TobetterunderstandattributesofART-associatedHIV-inducedT-cellresponsesthatmightbetherapeuticallyharnessed. + Methods.CD8 T-cellresponseswereevaluatedinsomeHIV-1chronicallyinfectedparticipantsofthe?xeddurationSTIsubstudy oftheDARTtrial.Magnitudes,breadths,andfunctionalityofIFN-γ andPerforinresponseswerecomparedinSTI(n = 42) andcontinuoustreatment(CT)(n = 46)beforeandafterasingleSTIcyclewhentheDARTSTItrialwasstoppedearlydueto inferiorclinicaloutcomeinSTIparticipants.Results.STIandCThadcomparablemagnitudesandbreadthsofmonofunctional CD8 + IFNγ and CD8 Perforin responses. However, STI was associated with signi?cant decline in breadth of bi-functional + + IFNγ )responses;P=.02,Mann-Whitneytest.Conclusions.STIinindividualsinitiatedontoARTat200CD4 T-cellcounts/μlsigni?cantlyreduce