Celiac Disease and Dermatologic Manifestations Many Skin Clue to Unfold Gluten-Sensitive Enteropathy英文文献资料.docVIP

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Celiac Disease and Dermatologic Manifestations Many Skin Clue to Unfold Gluten-Sensitive Enteropathy英文文献资料.doc

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Celiac Disease and Dermatologic Manifestations Many Skin Clue to Unfold Gluten-Sensitive Enteropathy英文文献资料

HindawiPublishingCorporation GastroenterologyResearchandPractice Volume2012,ArticleID952753,12pages doi:10.1155/2012/952753 ReviewArticle CeliacDiseaseandDermatologicManifestations: ManySkinCluetoUnfoldGluten-SensitiveEnteropathy MarziaCaproni, VeronicaBonciolini, AntoniettaD’Errico, 1 1 1 EmilianoAntiga,1,2andPaoloFabbri1 1 2 DivisionofDermatology,DepartmentofMedicalandSurgicalCriticalCare,UniversityofFlorence,50129Florence,Italy DepartmentofClinicalPhysiopathology,UniversityofFlorence,50139Florence,Italy CorrespondenceshouldbeaddressedtoMarziaCaproni,marzia.caproni@uni?.it Received12January2012;Revised13March2012;Accepted5April2012 AcademicEditor:GovindK.Makharia Copyright?2012MarziaCapronietal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Cutaneousmanifestationsofintestinaldiseasesareincreasinglyreportedbothintheadultandinthechildren,andthisassociation cannotlongerbeconsideredasimplerandom.Besidesthewell-knownassociationbetweenceliacdisease(CD)anddermatitis herpetiformis(DH),consideredasthecutaneousmanifestationofgluten-dependententeropathy,ismorefrequentlyreported alsotheassociationwithothermucocutaneousdiseases.Amongthesetherearebothautoimmune,allergic,andin?ammatory diseases,butalsoamoreheterogeneousgroupcalledmiscellaneous.Theknowledgeaboutpathogenic,epidemiological,clinical, anddiagnosticaspectsofCDisincreasinginrecentyearsaswellasthoseaboutDH,butsomeaspectsstillremaintobede?ned, inparticularthepossiblepathogeneticmechanismsinvolvedintheassociationbetweenbothCDandDHandCDandother immunologicalskindiseases.TheaimofthispaperistodescribetheskindiseasesfrequentlyassociatedwithCD,distinguishing themfromthosewhichhavearelationshipprobablyjustcoincidental. 1.Introduction organs and systems recently classi?ed as autoimmune, idiopathic,chromosomal,andmiscellaneous.Amongth