Cell and Molecular Biology Underpinning the Effects of PEDF on Cancers in General and Osteosarcoma in Particular英文文献资料.docVIP

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Cell and Molecular Biology Underpinning the Effects of PEDF on Cancers in General and Osteosarcoma in Particular英文文献资料.doc

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Cell and Molecular Biology Underpinning the Effects of PEDF on Cancers in General and Osteosarcoma in Particular英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2012,ArticleID740295,9pages doi:10.1155/2012/740295 ReviewArticle CellandMolecularBiologyUnderpinningtheEffectsofPEDFon CancersinGeneralandOsteosarcomainParticular VijayChandoluandCrispinR.Dass SchoolofBiomedicalandHealthSciences,VictoriaUniversity,Building6,StAlbans,VIC3021,Australia CorrespondenceshouldbeaddressedtoCrispinR.Dass,crispin.dass@.au Received24October2011;Revised9March2012;Accepted23March2012 AcademicEditor:SusanE.Crawford Copyright?2012V.ChandoluandC.R.Dass.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Cancerisbecominganincreasinglycommondiseaseinwhichabnormalcellsaggressivelygrow,invade,andmetastasize.Inthis paper,wereviewthebiologicalfunctionsofPEDF(pigmentedepithelium-derivedfactor)againstcancer,withafocusonapartic- ulartypeofbonecancercalledosteosarcoma.PEDFisa50kDaglycoproteinandisapotentinhibitorofangiogenesis,viaitsability todecreaseproliferationandmigrationofendothelialcells.ThispapercriticallyexaminestheanticanceractivitiesofPEDFviaits roleinantiangiogenesis,apoptosis-mediatedtumorsuppression,andincreasedtumorcelldi?erentiation.Recently,anorthotopic model of osteosarcoma was used to show that treatment with PEDF had the greatest impact on metastases, warranting an evaluationofPEDFe?cacyinothertypesofcancers. 1.Introduction PEDFisresponsiblefortheantiangiogenesisinvariousocu- larcompartments[6].Thesesigni?cantantiangiogenicprop- ertiesledthescientiststoshiftfocusontostudiesexamining thepotentialantitumouractivitiesofPEDF.PEDFexpression changes in the course of progression of di?erent tumour types[5].Researchersdidanumberofstudiesandshowed that there is opposite relation between PEDF levels, grade andmetastaticpotentialofprostatetumours[7],pancreatic adenocarcinoma[8],prostate,melanoma,ovarian,osteosar- coma,glioma[4],hepatocellular