Cell adhesion molecules and hyaluronic acid as markers of inflammation, fibrosis and response to antiviral therapy in chronic hepatitis C patients英文文献资料.docVIP

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Cell adhesion molecules and hyaluronic acid as markers of inflammation, fibrosis and response to antiviral therapy in chronic hepatitis C patients英文文献资料.doc

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Cell adhesion molecules and hyaluronic acid as markers of inflammation, fibrosis and response to antiviral therapy in chronic hepatitis C patients英文文献资料

Research Paper Mediators of Inflammation, 10, 253–258 (2001) O BJECTIVE:Celladhesionmolecules(intracellularadhe- Cell adhesion molecules and hyaluronic acid as markers of inflammation, fibrosis and response to antiviral therapy in chronic hepatitis C patients sion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)) and hyaluronic acid, markers of inflammation and fibrosis were monitored in hepatitis C patients to determine whether changes in plasma levels, during antiviral treatment, can predict long-term response to therapy. Methods: In 55 patients with chronic hepatitis C virus (HCV), 33 treated with interferon (IFN) and 22 treated with IFN + ribavirin, sera was collected prior to treatment, at 3 + 6 months of therapy and 6 months post-treatment. Levels of ICAM-1, VCAM-1 and hya- luronic acid were correlated with alanine amino- transferase levels, HCV-RNA-polymerase chain reac- tion status and histological fibrosis scoring. Results:AdecreaseinICAM-1levelsat3and6months of therapy, compared with pretreatment levels, was observed in responders to IFN + ribavirin therapy but this decrease in ICAM-1 levels was not evident follow- ing cessation of treatment. Hyaluronic acid levels, in both treatment groups, did not differ significantly betweenrespondersandnon-responders.Hyaluronic acidlevelsdidcorrelate,significantly,withdegreeof fibrosis whereas VCAM-1 levels were marginally increased only in patients with moderate (grade III) fibrosis. Esther Granot , Daniel Shouval and Yaffa Ashur 1,CA 2 2 1 Pediatric Gastroenterology Unit, Pediatrics Department and Liver Unit, Hadassah University 2 Hospital – Hebrew University-Hadassah Medical School, P.O. Box 12000, Jerusalem 91120, Israel CA Corresponding Author Tel: +972 2 6777111 Fax: +972 2 6434434 E-mail: etgranot@md2.huji.ac.il Conclusions: Monitoring of VCAM-1 and hyaluronic acid, during antiviral therapy, doe