Cellular Liver Regeneration after Extended Hepatic Resection in Pigs英文文献资料.docVIP

Cellular Liver Regeneration after Extended Hepatic Resection in Pigs英文文献资料.doc

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Cellular Liver Regeneration after Extended Hepatic Resection in Pigs英文文献资料

HindawiPublishingCorporation HPBSurgery Volume2009,ArticleID306740,7pages doi:10.1155/2009/306740 ResearchArticle CellularLiverRegenerationafterExtended HepaticResectioninPigs RuthLadurner,FrankTraub,MartinSchenk,AlfredK¨onigsrainer,andJ¨orgGlatzle DepartmentofGeneral,VisceralandTransplantSurgery,UniversityHospitalT¨ubingen,Hoppe-Seyler-Street3, D-72076T¨ubingen,Germany CorrespondenceshouldbeaddressedtoRuthLadurner,ruth.ladurner@med.uni-tuebingen.de Received21November2008;Accepted27January2009 RecommendedbyGuyMaddern Background.Theliverhasanenormouscapacitytoregenerateitself.Theaimofthisstudywastoevaluatewhethertheregeneration isduetohypertrophyorhyperplasiaoftheremnantliverafterextendedresectionandwhetheraportosystemicshuntisbene?cial. Materialandmethods.Anextendedlefthemihepatectomywasperformedin25pigs,andin14afterperformingaportosystemic shunt.Duringfollowup,liverregenerationwasestimatedbymacroscopicmarkerssuchaslivervolumeandsizeoftheportal?elds 2 2 [mm ]aswellastheamountofhepatocytesperportal?eldandtheamountofhepatocytespermm .Results.Regardlessofthe operationprocedure,thevolumeoftheremnantliverincreasedabout2.5foldattheendofthe?rstweekafterresection.Thesize oftheportal?eldsincreasedsigni?cantlyaswellasthenumberofhepatocytesintheportal?elds.Interestingly,thenumberof 2 hepatocytespermm remainedthesame.Conclusion.Afterextendedresection,liverregenerationwasachievedbyanextensive andsigni?canthyperplasiaofhepatocyteswithinthepreexistingportal?eldsandnotbydenovosynthesisofnewportal?elds. However,therewasnodi?erenceinliverregenerationregardingtheoperationprocedureperformedwithorwithoutportosystemic shunt. Copyright?2009RuthLadurneretal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. 1.Introduction speci?c genes are inserted or de

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