Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling英文文献资料.docVIP

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Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling英文文献资料.doc

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Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling英文文献资料

SAGE-HindawiAccesstoResearch InternationalJournalofIn?ammation Volume2011,ArticleID535241,13pages doi:10.4061/2011/535241 ReviewArticle CellularInterplaybetweenCardiomyocytesandNonmyocytesin CardiacRemodeling NorifumiTakeda1,2andIchiroManabe 2,3 1 2 3 DepartmentofCellandDevelopmentalBiologyandPennCardiovascularInstitute, PerelmanSchoolofMedicineattheUniversityofPennsylvania,Philadelphia,PA19104,USA DepartmentofCardiovascularMedicine,GraduateSchoolofMedicine,UniversityofTokyo,7-3-1Hongo,Bunkyo, Tokyo113-8655,Japan GlobalCOEProgram,GraduateSchoolofMedicine,UniversityofTokyo,Tokyo113-8655,Japan CorrespondenceshouldbeaddressedtoIchiroManabe,manabe-tky@umin.ac.jp Received22March2011;Revised28May2011;Accepted12June2011 AcademicEditor:MasanoriAikawa Copyright?2011N.TakedaandI.Manabe.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Cardiac hypertrophy entails complex structural remodeling involving rearrangement of muscle?bers, interstitial ?brosis,ac- cumulation of extracellular matrix, and angiogenesis. Many of the processes underlying cardiac remodeling have features in commonwithchronicin?ammatoryprocesses.Duringtheseprocesses,nonmyocytes,suchasendothelialcells,?broblasts,and immune cells, residing in or in?ltrating into the myocardial interstitium play active roles. This paper mainly addresses the functionalrolesofnonmyocytesduringcardiacremodeling.Inparticular,wefocusonthecommunicationbetweencardiomyo- cytesandnonmyocytesthroughdirectcell-cellinteractionsandautocrine/paracrine-mediatedpathways. 1.Introduction theprocessesunderlyingthesephenomenaarealsoseenin chronicin?ammatorydiseasesandaremediatedbycellular interactions among cardiomyocytes and nonmyocytes. In thispaper,wewillfocusonthefunctionalrolesofnonmy- ocytesandthecellularcommunicationongoingduringthe developmentofcardiachypertrophyandheartfailureunder noninfectiousandnon