Cellulases from Thermophilic Fungi Recent Insights and Biotechnological Potential英文文献资料.docVIP

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Cellulases from Thermophilic Fungi Recent Insights and Biotechnological Potential英文文献资料.doc

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Cellulases from Thermophilic Fungi Recent Insights and Biotechnological Potential英文文献资料

SAGE-HindawiAccesstoResearch EnzymeResearch Volume2011,ArticleID308730,9pages doi:10.4061/2011/308730 ReviewArticle CellulasesfromThermophilicFungi:RecentInsightsand BiotechnologicalPotential Duo-ChuanLi, An-NaLi, andAnastassiosC.Papageorgiou 1 1 2 1 2 DepartmentofEnvironmentalBiology,ShandongAgriculturalUniversity,Taian,Shandong271018,China TurkuCentreforBiotechnology,UniversityofTurkuandA?boAkademiUniversity,20521Turku,Finland CorrespondenceshouldbeaddressedtoAnastassiosC.Papageorgiou,tassos.papageorgiou@btk.? Received6June2011;Revised5September2011;Accepted7September2011 AcademicEditor:D.M.G.Freire Copyright?2011Duo-ChuanLietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Thermophilicfungalcellulasesarepromisingenzymesinproteinengineeringe?ortsaimedatoptimizingindustrialprocesses, suchasbiomassdegradationandbiofuelproduction.Thecloningandexpressioninrecentyearsofnewcellulasegenesfrom thermophilicfungihaveledtoabetterunderstandingofcellulosedegradationinthesespecies.Moreover,crystalstructuresof thermophilicfungalcellulasesarenowavailable,providinginsightsintotheirfunctionandstability.Thepresentpaperisfocused onrecentprogressincloning,expression,regulation,andstructureofthermophilicfungalcellulasesandthecurrentresearch e?ortstoimprovetheirpropertiesforbetteruseinbiotechnologicalapplications. 1.Introduction newthermostableenzymesforuseinmanybiotechnological applications,includingbiomassdegradation.Thermophilic cellulasesarekeyenzymesfore?cientbiomassdegradation. Their importance stems from the fact that cellulose swells at higher temperatures, thereby becoming easier to break down.Anumberofthermophilicfungihavebeenisolatedin recentyearsandthecellulasesproducedbytheseeukaryotic microorganisms have been puri?ed and characterized at both structural and functional level. This review aims