Candida Biofilms and the Host Models and New Concepts for Eradication英文文献资料.docVIP

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Candida Biofilms and the Host Models and New Concepts for Eradication英文文献资料.doc

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Candida Biofilms and the Host Models and New Concepts for Eradication英文文献资料

HindawiPublishingCorporation InternationalJournalofMicrobiology Volume2012,ArticleID845352,16pages doi:10.1155/2012/845352 ReviewArticle CandidaBio?lmsandtheHost: ModelsandNewConceptsforEradication H′el`eneTournu1,2andPatrickVanDijck 1,2 1 LaboratoryofMolecularCellBiology,InstituteofBotanyandMicrobiology,KatholiekeUniversiteitLeuven, Flanders,3001Leuven-Heverlee,Belgium 2 DepartmentofMolecularMicrobiology,VIB,KasteelparkArenberg31,Flanders,3001,Leuven-Heverlee,Belgium CorrespondenceshouldbeaddressedtoH′el`eneTournu,helene.tournu@mmbio.vib-kuleuven.be Received7August2011;Accepted30September2011 AcademicEditor:AriannaTavanti Copyright?2012H.TournuandP.VanDijck.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Bio?lmsde?nemono-ormultispeciescommunitiesembeddedinaself-producedprotectivematrix,whichisstronglyattachedto surfaces.Theyoftenareconsideredageneralthreatnotonlyinindustrybutalsoinmedicine.Theyconstituteapermanentsource ofcontamination,andtheycandisturbtheproperusageofthematerialontowhichtheydevelop.Thispaperrelatestosomeofthe mostrecentapproachesthathavebeenelaboratedtoeradicateCandidabio?lms,basedonthevaste?ortputinever-improving modelsofbio?lmformationinvitroandinvivo,includingnovel?owsystems,high-throughputtechniquesandmucosalmodels. Mixedbio?lms,sustainingantagonistorbene?cialcooperationbetweenspecies,andtheirinterplaywiththehostimmunesystem arealsoprevalenttopics.Alternativestrategiesagainstbio?lmsincludethelocktherapyandimmunotherapyapproaches,and materialcoatingandimprovements.Thehost-bio?lminteractionsarealsodiscussed,togetherwiththeirpotentialapplicationsin Candidabio?lmelimination. 1.Introduction super?cialsitessuchasskinandnails,tomedicalimplants andcatheters[6].C.albicansbio?lmdevelopmenthasbeen characterizedinvariousmodelsystemsbothinvitroandin vivo [7–9] and consists of distinct phases. The initial step consist