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Cannabinoids A New Group of Agonists of PPARs英文文献资料.doc

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Cannabinoids A New Group of Agonists of PPARs英文文献资料

HindawiPublishingCorporation PPARResearch Volume2007,ArticleID23513,7pages doi:10.1155/2007/23513 ReviewArticle Cannabinoids:ANewGroupofAgonistsofPPARs YanSunandAndyBennett SchoolofBiomedicalSciences,UniversityofNottinghamMedicalSchool,NottinghamNG72UH,UK CorrespondenceshouldbeaddressedtoYanSun,stxys3@nottingham.ac.uk Received30April2007;Accepted13September2007 RecommendedbyJ.VandenHeuvel Cannabinoidshavebeenusedmedicinallyandrecreationallyforthousandsofyearsandtheire?ectswereproposedtooccurmainly viaactivationoftheG-protein-coupledreceptorCB1/CB2(cannabinoidreceptor1/2).Discoveryofpotentsyntheticanalogsof thenaturalcannabinoidsasclinicallyusefuldrugsisthesustainedaimofcannabinoidresearch.Thisdemandsthatthesenew compoundsbefreeofthepsychotropice?ectsthatconnectedwiththerecreationaluseofcannabinoids.Inpreclinicalstudies cannabinoidsdisplayedmanyofthecharacteristicsofnonsteroidalanti-in?ammatorydrugs(NSAIDs)anditseemstobefreeof unwantedsidee?ects.Anincreasingnumberoftherapeuticactionsofcannabinoidarebeingreportedthatdonotappeartobe mediatedbyeitherCB1orCB2,andrecentlynuclearreceptorsuperfamilyPPARs(peroxisome-proliferator-activatedreceptors) havebeensuggestedasthetargetofcertaincannabinoids.Thisreviewsummarizestheevidenceforcannabinoidactivationon PPARsandpossibleassociatedremedialpotentials. Copyright?2007Y.SunandA.Bennett. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. 1. INTRODUCTION inheartrateandadecreaseinbloodpressure.Inaddition thereisevidencethatcannabinoidscanalleviatespasticity, lower the heightened intraocular pressure associated with glaucoma,controlthevomitingandnauseaassociatedwith cancerchemotherapy,andreducepain.Thelong-terme?ects ofcannabinoidexposureincludealternationsinthelevelsof maleandfemalesexualhormones,possibleteratogenicef- fects,immunosuppression,andpossiblephysicaldependence onthecompou