Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts英文文献资料.docVIP

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Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts英文文献资料.doc

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Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts英文文献资料

SAGE-HindawiAccesstoResearch EnzymeResearch Volume2011,ArticleID523420,8pages doi:10.4061/2011/523420 ReviewArticle CanonicalandAlternativePathwaysin Cyclin-DependentKinase1/CyclinBInactivationupon M-PhaseExitinXenopuslaevisCell-FreeExtracts JacekZ.KubiakandMohammedElDika CellCycleGroup,InstituteofGeneticsDevelopment,UniversityofRennes1,CNRS-UMR6061,FacultyofMedicine, 2AvenueProf.L′eonBernard,CS34317,35043RennesCedex,France CorrespondenceshouldbeaddressedtoJacekZ.Kubiak,jacek.kubiak@univ-rennes1.fr Received25February2011;Revised1April2011;Accepted18April2011 AcademicEditor:HeungChinCheng Copyright?2011J.Z.KubiakandM.ElDika.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Cyclin-DependentKinase1(CDK1)isthemajorM-phasekinaseknownalsoastheM-phasePromotingFactororMPF.Studies performedduringthelastdecadehaveshownmanydetailsofhowCDK1isregulatedandalsohowitregulatesthecellcycle progression.Xenopuslaevis cell-freeextractswerewidely usedtoelucidatethedetailsandtoobtainaglobalview oftherole ofCDK1inM-phasecontrol.CDK1inactivationuponM-phaseexitisaprimordialprocessleadingtotheM-phase/interphase transitionduringthecellcycle.HerewediscusstwocloselyrelatedaspectsofCDK1regulationinXenopuslaeviscell-freeextracts: ?rstly,howCDK1becomesinactivatedandsecondly,howotheractors,likekinasesandphosphatasesnetworkand/orspeci?c inhibitors,cooperatewithCDK1inactivationtoassuretimelyexitfromtheM-phase. 1.Introduction a handful of CDKs are expressed (CDK1, CDK2, CDK5, CDK9;ourunpublisheddata).TwomajorCDKstakingpart in cell cycle regulation are CDK1 and CDK2. Only CDK1 seems to be involved in M-phase regulation, while CDK2 isamajorplayerinS-phaseprogression.Thesimilarity in three-dimensional structure of these two kinases helps to understandsomeaspectsoftheirregulation. CDK1activitypicksonlyforaveryshortperiodoftime uponG2/Mtransitionandfallsdown