Brachystemma calycinum D. Don Effectively Reduces the Locomotor Disability in Dogs with Naturally Occurring Osteoarthritis A Randomized Placebo-Controlled Trial英文文献资料.docVIP

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Brachystemma calycinum D. Don Effectively Reduces the Locomotor Disability in Dogs with Naturally Occurring Osteoarthritis A Randomized Placebo-Controlled Trial英文文献资料.doc

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Brachystemma calycinum D. Don Effectively Reduces the Locomotor Disability in Dogs with Naturally Occurring Osteoarthritis A Randomized Placebo-Controlled Trial英文文献资料

HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2012,ArticleID646191,9pages doi:10.1155/2012/646191 ResearchArticle BrachystemmacalycinumD.DonEffectivelyReduces theLocomotorDisabilityinDogswithNaturallyOccurring Osteoarthritis:ARandomizedPlacebo-ControlledTrial JohanneMartel-Pelletier, MaximMoreau,1,2BertrandLussier,2,3Jean-PierrePelletier,2 2 DominiqueGauvin,1,2andEricTroncy 1,2 ChristianB′edard, 4 1 2 3 4 ResearchGroupinAnimalPharmacologyofQuebec(GREPAQ),FacultyofVeterinaryMedicine,Universit′edeMontr′eal,C.P.5000, Saint-Hyacinthe,QC,CanadaJ2S7C6 OsteoarthritisResearchUnit,CentreHospitalierdel’Universit′edeMontr′eal(CRCHUM),Notre-DameHospital, 1560SherbrookeStreetEast,Montreal,QC,CanadaH2L4M1 DepartmentofClinicalSciences,FacultyofVeterinaryMedicine,Universit′edeMontr′eal,C.P.5000,Saint-Hyacinthe, QC,CanadaJ2S7C6 DepartmentofPathologyandMicrobiology,FacultyofVeterinaryMedicine,Universit′edeMontr′eal,C.P.5000,Saint-Hyacinthe, QC,CanadaJ2S7C6 CorrespondenceshouldbeaddressedtoEricTroncy,eric.troncy@umontreal.ca Received7April2012;Accepted30May2012 AcademicEditor:VincenzoDeFeo Copyright?2012MaximMoreauetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Objective.Theaimofthisrandomizedplacebo-controlledtrialwastoevaluatethebene?ciale?ectofawholeplantextractof BrachystemmacalycinumD.Don(BCD)innaturallyoccurringosteoarthritis(OA)indogs.Methods.Dogshadsti?e/hipOAand poorlimbloadingbasedonthepeakoftheverticallyorientedgroundreactionforce(PVF)measuredusingaforceplatform.At baseline,PVFandcase-speci?coutcomemeasureofdisability(CSOM)wererecorded.Dogs(16pergroup)werethenassigned toreceiveBCD(200mg/kg/day)oraplacebo.ThePVFwasmeasuredatweek(W)3andW6.Locomotoractivitywasrecorded throughoutthestudydurationusingcollar-mountedaccelerometer,andCSOMwasassessedbiweekl