Cannabinoids for the Treatment of Schizophrenia A Balanced Neurochemical Framework for Both Adverse and Therapeutic Effects of Cannabis Use英文文献资料.docVIP

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Cannabinoids for the Treatment of Schizophrenia A Balanced Neurochemical Framework for Both Adverse and Therapeutic Effects of Cannabis Use英文文献资料.doc

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Cannabinoids for the Treatment of Schizophrenia A Balanced Neurochemical Framework for Both Adverse and Therapeutic Effects of Cannabis Use英文文献资料

HindawiPublishingCorporation SchizophreniaResearchandTreatment Volume2011,ArticleID501726,9pages doi:10.1155/2011/501726 ReviewArticle CannabinoidsfortheTreatmentofSchizophrenia? ABalancedNeurochemicalFrameworkforBothAdverseand TherapeuticEffectsofCannabisUse CarissaM.Coulston,1,2MichaelPerdices,1,3AntonyF.Henderson,1andGinS.Malhi 1,2 1 2 3 DisciplineofPsychiatry,SydneyMedicalSchool,UniversityofSydney,NSW2006,Australia DepartmentofPsychiatry,CADEClinic,RoyalNorthShoreHospital,St.Leonards,Sydney,NSW2065,Australia DepartmentofNeurology,RoyalNorthShoreHospital,St.Leonards,Sydney,NSW2065,Australia CorrespondenceshouldbeaddressedtoGinS.Malhi,gin.malhi@.au Received17November2009;Revised29April2010;Accepted14June2010 AcademicEditor:DavidC.Henderson Copyright?2011CarissaM.Coulstonetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Recentstudieshavefoundthatcannabinoidsmayimproveneuropsychologicalperformance,amelioratenegativesymptoms,and haveantipsychoticpropertiesforasubgroupoftheschizophreniapopulation.These?ndingsareincontrasttothelongstanding historyofadverseconsequencesofcannabisuse,predominantlyonthepositivesymptoms,andabalancedneurochemicalbasis for these opposing views is lacking. This paper details a review of the neurobiological substrates of schizophrenia and the neurochemicale?ectsofcannabisuseinthenormalpopulation,inbothcortical(inparticularprefrontal)andsubcorticalbrain regions.Theaimofthispaperistoprovideaholisticneurochemicalframeworkinwhichtounderstandhowcannabinoidsmay impair,orindeed,servetoamelioratethepositiveandnegativesymptomsaswellascognitiveimpairment.Directionsinwhich futureresearchcanproceedtoresolvethediscrepanciesarebrie?ydiscussed. 1.Introduction The high prevalence of cannabis use in schizophrenia combined with observations that cannabis exacerbates the positive symptoms has driven research to investiga