Cellular responding kinetics based on a model of gene regulatory networks under radiotherapy英文文献资料.docVIP

Vol.2, No.2, 137-146 (2010) Health doi:10.4236/health.2010.22021 Cellular responding kinetics based on a model of gene regulatory networks under radiotherapy Jin-Peng Qi , Yong-Sheng Ding , Shi-Huang Shao , Xian-Hui Zeng , Kuo-Chen Chou 1,3* 1,2,3* 1 1 1,2 1 2 3 College of Information Sciences and Technology, Donghua University, Shanghai, China Gordon Life Science Institute, San Diego, USA; qipengkai@126.com, ysding@ Engineering Research Center of Digitized Textile Fashion Technology, Ministry of Education, Donghua University, Shanghai, China Received 16 November 2009; revised 3 December 2009; accepted 8 December 2009. ABSTRACT is the most commonly known specific target of mutation in tumorigenesis [4]. Abnormalities in the P53 have been identified in over 60% of human cancers and the status of P53 within tumor cells has been proposed to be one of the determinant response to anticancer therapies [3,4]. Con- trolled radiotherapy studies show the existence of a strong biologic basis for considering P53 status as a radiation predictor [3,5]. Therefore, the status of P53 in tumor cell can be considered as a predictor for long-term bio- chemical control during and after radiotherapy [6-8]. Recently, several models have been proposed to ex- plain the damped oscillations of P53 in cell populations [9-12]. However, the dynamic mechanism of the sin- gle-cell responses is not completely clear yet, and the complicated regulations among genes and their signal pathways need to be further addressed, particularly under the condition of acute IR. Many studies have indicated that introducing novel mathematical and computational approaches can stimu- late in-depth investigation into various complicated bio- logical systems (see, e.g.,