Centella asiatica Attenuates D-Galactose-Induced Cognitive Impairment, Oxidative and Mitochondrial Dysfunction in Mice英文文献资料.docVIP

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Centella asiatica Attenuates D-Galactose-Induced Cognitive Impairment, Oxidative and Mitochondrial Dysfunction in Mice英文文献资料.doc

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Centella asiatica Attenuates D-Galactose-Induced Cognitive Impairment, Oxidative and Mitochondrial Dysfunction in Mice英文文献资料

SAGE-HindawiAccesstoResearch InternationalJournalofAlzheimer’sDisease Volume2011,ArticleID347569,9pages doi:10.4061/2011/347569 ResearchArticle CentellaasiaticaAttenuatesD-Galactose-InducedCognitive Impairment,OxidativeandMitochondrialDysfunctioninMice AnilKumar,AtishPrakash,andSamritaDogra PharmacologyDivision,UniversityInstituteofPharmaceuticalSciences,UGCCenterforAdvancedStudies, PanjabUniversity,Chandigarh-160014,India CorrespondenceshouldbeaddressedtoAnilKumar,kumaruips@ Received1November2010;Accepted26January2011 AcademicEditor:CesareMancuso Copyright?2011AnilKumaretal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. D-galactoseinducedneurotoxicityiswellknownmodelforstudyingagingandrelatedoxidativedamageandmemoryimpairment. Aging is a biological process, characterized by the gradual loss of physiological functions by unknown mechanism. Centella asiatica,Indianpennyworthasbeendocumentedinthetreatmentofvariousneurologicaldisordersincludingaging.Therefore, presentstudyhasbeenconductedinordertoexplorethepossibleroleofCentellaasiaticaagainstD-galactoseinducedcognitive impairment,oxidativeandmitochondrialdysfunctioninmice.ChronicadministrationofD-galactose(100mg/kgs.c.)foraperiod ofsixweekssigni?cantlyimpairedcognitivetask(bothinbothMorriswatermazeandelevatedplusmaze)andoxidativedefense (Increased lipid peroxidation, nitrite concentration and decreased activity of superoxide dismutase, catalaseand non-protein thiols)andimpairedmitochondrialcomplex(I,IIandIII)enzymesactivitiesascomparedtoshamgroup.SixweeksCentella asiatica(150and300mg/kg,p.o)treatmentsigni?cantlyimprovedbehavioralalterations,oxidativedamageandmitochondrial enzymecomplexactivitiesascomparedtocontrol(D-galactose).Centellaasiaticaalsoattenuatedenhancedacetylcholineesterase enzymelevelinD-galactosesenescencemice.Presentstudyhighlightstheprotectivee?ectofCentellaasia